MEF2D

MEF2D
معین‌کننده‌ها
نام‌های دیگر	MEF2D, myocyte enhancer factor 2D
شناسه‌های بیرونی	OMIM: 600663; MGI: 99533; HomoloGene: 4327; GeneCards: MEF2D; OMA:MEF2D - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۱ (انسان)
پایان	156,500,779 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۳ (موش)
پایان	88,079,393 bp
الگوی گسترش RNA
	بیشترین بیان در
	muscle of thigh; ; tibial arteries; ; saphenous vein; ; apex of heart; ; gastric mucosa;
	بیشترین بیان در
	Ileal epithelium; ; neural layer of retina; ; perirhinal cortex; ; CA3 field; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex;
	داده‌های بیشتر بیان
	; ;
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; پیوند پروتئینی; protein heterodimerization activity; enzyme binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	سیتوپلاسم; intracellular membrane-bounded organelle; نوکلئوپلاسم; هسته سلول;
فرایند زیستی	دگرگونی یاخته‌; regulation of transcription, DNA-templated; chondrocyte differentiation; adult heart development; muscle organ development; استخوان‌سازی درون‌غضروفی; transcription by RNA polymerase II; transcription, DNA-templated; جنین‌شناسی دستگاه عصبی مرکزی; multicellular organism development; positive regulation of transcription, DNA-templated; osteoblast differentiation; skeletal muscle cell differentiation; positive regulation of transcription by RNA polymerase II; مرگ برنامه‌ریزی‌شده یاخته; positive regulation of vascular associated smooth muscle cell proliferation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4209
	17261
	ENSG00000116604
	ENSMUSG00000001419
	Q14814
	Q63943
	NM_001271629; NM_005920
	NM_133665; NM_001310587; NM_001310593
	NP_001258558; NP_005911
	NP_001297516; NP_001297522; NP_598426
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور تقویت‌کننده 2D اختصاصی یاخته ماهیچه‌ای (انگلیسی: Myocyte-specific enhancer factor 2D) یک پروتئین است که در انسان توسط ژن «MEF2D» کُدگذاری می‌شود.^[۵]^[۶]

این پروتئین با فاکتور رونویسی Sp1^[۷] تعامل پروتئین-پروتئین دارد.

منابع

1 2 3 GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001419 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. PMID 8269842.
↑ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)". Archived from the original on 16 ژوئن 2024.
↑ Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.

مشارکت‌کنندگان ویکی‌پدیا. «MEF2D». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۷ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (Oct 1995). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–711. doi:10.1006/geno.1995.9007. PMID 8575763.
Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (Jan 1999). "Regulation of the MEF2 family of transcription factors by p38". Molecular and Cellular Biology. 19 (1): 21–30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528.
Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (Nov 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology. 19 (11): 7816–7827. doi:10.1128/mcb.19.11.7816. PMC 84849. PMID 10523670.
Lu J, McKinsey TA, Nicol RL, Olson EN (Apr 2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proceedings of the National Academy of Sciences of the United States of America. 97 (8): 4070–4075. doi:10.1073/pnas.080064097. PMC 18151. PMID 10737771.
Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD (Jun 2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family". The Journal of Biological Chemistry. 275 (24): 18534–18540. doi:10.1074/jbc.M001573200. PMID 10849446.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH (Mar 2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D". The Journal of Biological Chemistry. 276 (10): 7575–7585. doi:10.1074/jbc.M004625200. PMID 11096067.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.
Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA (Mar 2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 99 (6): 3974–3979. doi:10.1073/pnas.022036399. PMC 122633. PMID 11904443.
Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/S0161-5890(02)00055-X. PMID 12213324.
Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA (Oct 2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival". The Journal of Biological Chemistry. 278 (42): 41472–41481. doi:10.1074/jbc.M307245200. PMID 12896970. {{cite journal}}: پیوند خارجی در |title= وجود دارد (کمک)نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Grégoire S, Yang XJ (Mar 2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors". Molecular and Cellular Biology. 25 (6): 2273–2287. doi:10.1128/MCB.25.6.2273-2287.2005. PMC 1061617. PMID 15743823.
Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (May 2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–813. doi:10.1038/sj.leu.2403684. PMID 15744350.

پیوند به بیرون

MEF2D protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001419 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8269842-5] Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. PMID 8269842.

[entrez-6] "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)". Archived from the original on 16 ژوئن 2024.

[pmid12213324-7] Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.

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