Recent posts tagged bioinformatics

When a patient takes several medications at once, two of them can interact in ways that cause real harm. DrugBank catalogues 86 distinct mechanisms for how this happens — one drug slowing another's metabolism, increasing its toxicity, blunting its ef...

We just officially open-sourced seosiri-biorobotics v1.0.0, a stateless, local-first Model Context Protocol MCP server designed to bridge the integration gap between biological datasets and physical robotic actuators. 🛠️ The Architecture: Decoupling...

E155 and E215 at 6.03 Å - exactly the nucleophile/acid-base separation expected for a GH5 retaining endoglucanase. This step matters. If I had accepted the literature numbering without checking, I would have fixed the wrong residues and the constra...

Antimicrobial resistance is projected to kill 10 million people annually by 2050 - more than cancer. Antimicrobial peptides AMPs are one of the most promising therapeutic classes to fight it. They're cationic, membrane-disrupting, and bacteria strugg...

A step-by-step walkthrough of my multi-sample single-cell RNA sequencing project - written for anyone curious about how computational biology actually works Before we start - what is this article actually about? Imagine being able to take a tiny s...

One of the most frustrating puzzles in cancer biology: some lung cancer patients respond brilliantly to immunotherapy. Others don't respond at all. The tumour microenvironment TME, the ecosystem of immune, stromal, and cancer cells that surrounds a t...

Alzheimer's disease affects over 55 million people worldwide, yet the precise molecular changes happening inside individual brain cells remain poorly understood. I wanted to dig into that question - not at the tissue level, but at single-cell resolut...

In short: PYRHELIX is an offline dual-control release gate for sensitive BIO/PII artifacts. It does not replace perimeter security, compliance review, or clinical judgment. It closes one specific gap: no single actor, key, or approval should be able ...

When a Health-AI Release Becomes a Governance Surface !2https://coderlegion.com/?qa=blob&qablobid=6341999130821584442 Biotech and health-AI didn't slow down in 2026. By June, the Flamehaven team's tracking of disclosed biotechnology equity rounds...

💡 Note: This is not an argument to dismiss the Nature Medicine paper. It is an argument for stronger validation infrastructure around medical AI benchmarks before practice-shaping claims become settled wisdom. Two Critics, Two Reasonable Conclusion...

Not just a new framework, but a clearer answer to what the score means, why the report exists, and how the artifact should be read. The real change in v1.8.0 through v1.8.4 was not that STEM BIO-AI cited one more framework. The real change was th...

Prologue: The Mirage & The Pivot In the summer of 2024, our team began with an ambition that felt almost impossible: to use frontier AI for drug discovery, theoretical physics, and problems that seemed unreachable. We imagined systems that could re...

!coverhttps://coderlegion.com/?qa=blob&qablobid=4234498897804287785 > When a repository carries this kind of pedigree, people stop asking questions. Runchuan-BU/BioClaw 1 — a biomedical AI assistant published on bioRxiv on April 14, 2026 by a multi...

!Beyond Repo Scanninghttps://dev-to-uploads.s3.amazonaws.com/uploads/articles/kyj7biyn850iewno8ywf.png This is the second half of the same 1.7.x transition. In the previous post, I wrote about calibration governance: how STEM BIO-AI keeps score aut...

When Control Becomes Authority: Calibration Governance in STEM BIO-AI 1.7.x Control slowly becomes authority when nobody marks the boundary. That is the calibration problem I kept running into while building STEM BIO-AIhttps://github.com/flamehave...

Earlier in this series, I wrote about why bio/medical AI repositories need more than benchmarks, what I learned after auditing 10 public repositories, and why an AI auditor itself needs a memory contract. That work led to STEM-AI v1.1.2 and the MICA...

!Image descriptionhttps://dev-to-uploads.s3.amazonaws.com/uploads/articles/1fj5kfblnvz80fjttvnl.png > Previous article: > How Auditing 10 Bio-AI Repositories Shaped STEM-AIhttps://dev.to/flamehaven01/how-auditing-10-bio-ai-repositories-shaped-stem-ai...

> No efficacy, causal, or clinical claims are made in this report. RExSyn is an experimental Bio-AI governance pipeline. You do not need to know the earlier experiments to read this report. Most AI pipeline reports ask one question: Did the system...