
ã2ã¡ãŒãã«ã®å¥è·¡ããâ现èã«ç§ããããDNAã®ç¥ç§â
åºç« ïŒæããããŸããå®å®ã®èšèšå³
ç§ãã¡äººéã®é«ã«ã¯ãåã2ã¡ãŒãã«ã®DNAãšããå¥è·¡ã®èšèšå³ãã37å åãç¹°ãè¿ãå»ãŸããŠãããšããäºå®ããåãã§ããããïŒ
现èã®çŽåŸã¯ããã10ãã€ã¯ãã¡ãŒãã«ååŸãïŒãã€ã¯ãã¡ãŒã¿ãŒã¯1ããªã¡ãŒãã«ã®1000åã®1ïŒ
ãã®å°ããªç©ºéã«ãé«å¯åºŠã§æ ŒçŽãããæ
å ±éã¯ããŸãã«å®å®ã®èšèšå³ãšåŒã¶ã«ãµãããããã®ã§ãã
ãããããããã®DNAããã¹ãŠç¹ãåããããšãã®é·ãã¯ãå®ã«740åããã¡ãŒãã«ã
ããã¯ãç©ççã«ã¯ãå°çã®èµ€éïŒçŽ4äžkmïŒã185äžåšããããã¯ãå°çãšå€ªéœã®éïŒ1å5000äžkmïŒãçŽ250åŸåŸ©ã§ããã»ã©ã®âåœã®èºæâãšãªãã®ã§ãã
ãã®ãããªå¥è·¡ã®âæ å ±ã®æãããã¿âããç§ãã¡ã¯ç¡æèã®ãã¡ã«æ¥ã å©çšããŠããã®ã§ãã
ãšããããç§ãã¡ããããŸã§ãèšèšå³ããšããŠæ±ã£ãŠããDNAã®ãã¡ãå®éã«ã¿ã³ãã¯è³ªã®èšèšã«é¢ãã£ãŠããé åã¯ããã3%ã«éããŸãããæ®ãã®97%ã¯âãžã£ã³ã¯DNAâãšåŒã°ããé·ããç¡æå³ãªé åã ãšèããããŠããŸããã
ããããããã«éåæãæ±ããã«ã¯ããããŸãããããã»ã©ç·»å¯ã«æ ŒçŽãããæ å ±ã®å€§éšåãç¡æå³ã§ããã¯ããããã§ããããïŒ
ãããç§ãã¡ã¯ãããŸã è§£æã§ããŠããªãã ãããšããè¬èãªç«å Žã«ç«ã€ã¹ãã§ã¯ãªãã§ãããããç§åŠã®èšèã§ãæå³ããªãããšåãæšãŠãŠããŸãããšã§ãéèŠãªççãèŠéããŠããŸã£ãŠããå¯èœæ§ããããã®ã§ãã
è¿å¹Žã§ã¯ãããžã£ã³ã¯DNAããéºäŒåã®ãªã³ã»ãªãã®å¶åŸ¡ãããšããžã§ããã£ãã¯ãªç°å¢å¿çã«æ·±ãé¢ãã£ãŠããããšãæããã«ãªãã€ã€ãããŸããããã¯ãçåœãšã¯åãªããã³ãŒããã®éåã§ã¯ãªããç°å¢ã»èšæ¶ã»éžæããå å ããæ å ±äœã§ãããšããå¯èœæ§ã瀺ããŠããŸãã
ãããªç²Ÿç·»ãªæ§é ã«ã人éãæãå ããããšããŠããçŸåšãéºäŒåç·šéæè¡ã¯ãæ²»çãã®å¯èœæ§ãšãšãã«ããèšèšè ã«ãªãããšããå¹»æ³ãã人é¡ã«ãããããŸããã
æãããŠãããã¯ã塿ºããªã®ããã岿
¢ããªã®ãã
ç§ãã¡ã¯ãã§ã«ããã³ãã©ã®ç®±ã«æããããŠããŸã£ãã®ãããããŸããã
第1ç« ïŒDNAã®æ§é çå¥è·¡
â çåœæ å ±ã®âæãããã¿âæè¡ â
DNAãšã¯ãããªãã·ãªãæ žé žïŒDeoxyribonucleic AcidïŒãã®ç¥ã§ããããã¹ãŠã®çåœäœã«å ±éããçåã®ã³ãŒããå å ããååæ§é äœã§ãã人éã®å Žåããã®DNAã¯30å察以äžã®å¡©åºé åã§æ§æãããçŽ2äžã®éºäŒåã«åãããŠååšããŠããŸãã
ããããçã«é©ãã¹ãã¯ãã®ç©ççæ§é ã§ãã1æ¬ã®DNAã¯ããã2ã¡ãŒãã«ã®é·ãããããç§ãã¡ã®é«ã«ããããã37å åã®çްèãããããã®æ žå ã«ãå®å šãªã³ããŒãšããŠæ ŒçŽãããŠããŸãã
â æ¡å€ãã®âå§çž®æè¡â
çŽåŸ10ãã€ã¯ãã¡ãŒãã«ååŸã®çŽ°èæ žã®äžã«2ã¡ãŒãã«ãã®DNAãåããããŠãããšããã®ã¯ãçŸä»£ã®ã©ããªå§çž®ã¢ã«ãŽãªãºã ãããã¯ããã«æŽç·Žããããè¶ é«å¯åºŠæ ŒçŽæè¡ãã§ãããšãããŸãã
ãã®æ ŒçŽã«ã¯ä»¥äžã®ãããªå€æ®µéæ§é ãååšããŠããŸãïŒ
äºéèºææ§é ã§ããŸãç·ç¶ã®é åãèºæç¶ã«å§çž®
ãã®DNAããã¹ãã³ãšããã¿ã³ãã¯è³ªã³ã¢ã«å·»ãä»ããŠãããŒãºç¶ãã«äžŠã³ããã¯ã¬ãªãœãŒã ãšããæ§é ã圢æ
ãã¯ã¬ãªãœãŒã å士ãæãšãªããã¯ãããã³ç¹ç¶ãšããŠããã«å·»ãã
æçµçã«ã¯æè²äœãšããŠæ žå ã«æããããŸãã
ããããã®æãããã¿ã¯ãåãªãâåçŽâã§ã¯ãªããåçãªã¢ã¯ã»ã¹æ§ãç¶æãããç¶æ ã§è¡ãããŠããŸããå¿ èŠãªæ å ±ã¯ããã«âã»ã©ããâãèªã¿åºããããŸãæ ŒçŽããããã€ãŸããããã¯éçæ§é ã§ã¯ãªããæ©èœæ§ã䌎ãâçãããã©ãŒãããâãªã®ã§ãã
â æ¯é¡ãªãæ å ±å¯åºŠ
ãããã®DNAã®æ å ±éãæåã«çœ®ãæããå Žåãèšå€§ãªå³æžé€šãäœçŸãšç©ã¿äžããã«çããæ å ±ãã1ã€ã®çްèã®äžã«ååšããŠããããšã«ãªããŸãã
30åå¡©åºå¯Ÿã®äžŠã³ãã
ã»ã¢ããé
žé
åãæ±ºå®ãã
ã»é
µçŽ ãçã¿åºãã
ã»çްèå
ã®ãã¹ãŠã®ä»£è¬ããã»ã¹ãèšèšãã
ã»åã
ã®äœè³ªãç¹æ§ãåå¿æ§ãå
ç«æ§ãŸã§ãå·Šå³ããŠããã
ãã®æ å ±å¯åºŠã®èåŸã«ã¯ããã ã®ãããŒã¿ãã§ã¯ãªããâç§©åºããã£ã塿ºâãååšããŠããããã«ããæããŠããŸãã
â DNAã¯âæ§é èšèªâã§ãã
ç§ãã¡ã¯ã€ããDNAããã³ãŒããããåœä»€åããšããŠç·çã«çè§£ããããšããŸãããããè¿å¹Žã§ã¯ãDNAã®äžæ¬¡å çã»æéçãªæ§é ã®æå³æ§ã«ã泚ç®ãéãŸã£ãŠããŸãã
ã©ã®é åãã©ãã«äœçœ®ããã
å·»ãã€ãã®è§åºŠããã¹ãã³ä¿®é£Ÿã®æç¡
ä»ã®ã¿ã³ãã¯è³ªãšã®ç©ºéçè·é¢ãæ¥è§Šã®é »åºŠ
æç³»åã«å€åããâ圢âã®ãã€ãããºã
ãããããã¹ãŠãâã©ã®éºäŒåããã€ãã©ãã§ãã©ãã ãåããâãšããæ å ±ã«çŽçµããŠããããšãããã£ãŠããã®ã§ããDNAã¯ãæ§é ãã®ãã®ãæå³ãæã€ç«äœçãªææ³æ§é ãåããããŸãã«âæ å ±ãå ·çŸåããçåœäœâã§ãããšãããã®ã§ãã
2ã¡ãŒãã«ã®æ å ±ãã10ãã¯ãã³ã®ç©ºéã«æ ŒçŽãããªããã€å³åº§ã«ã¢ã¯ã»ã¹ã»å€æã»åºåã§ããããã®ä»çµã¿ããç§ãã¡ã®é«ã¯åœããåã®ããã«äœ¿ãç¶ããŠããŸãã
ãã®ç¬¬1ç« ã§ã¯ãDNAãšããâç©è³ªâããç©çã»ååŠã»æ å ±å·¥åŠã»èžè¡ãå å ããç·åæ§é äœã§ããããšãæããã«ããŠããŸããã
第2ç« ïŒãžã£ã³ã¯DNAåè
â æªè§£æé åã«æœãç¥æ§ â
人é¡ãã²ãã ïŒå šéºäŒæ å ±ïŒãè§£èªãå§ãããšããç§åŠè ãã¡ã¯å€§ããªéåæãæ±ããŸããã30å察ã«ãåã¶å¡©åºé åã®äžã§ãå®éã«ã¿ã³ãã¯è³ªã®åæã«é¢ãã£ãŠããâã³ãŒãã£ã³ã°é åâã¯ããã3%ã«éããªãã£ãã®ã§ãã
æ®ãã®97%ã¯ããã°ãâãžã£ã³ã¯DNAâãšåŒã°ããŠããŸãããããã¯ãã圹ã«ç«ããªãããé²åã®åæ®ããšãã£ãèšèãšãšãã«ãããããçç©åŠçãªãŽãã§ãããã®ããã«æ±ãããŠããã®ã§ãã
ãããè¿å¹Žããã®âæ²é»ããŠããæ å ±âã«ãããçåœã®æ¬è³ªãé ãããŠããå¯èœæ§ã瀺ããå§ããŠããŸãã
â æ©èœããâç¡æå³âââæå³ã®åå®çŸ©
éã³ãŒãDNAã®äžéšã¯ã次ã®ãããªæ©èœç圹å²ãæ ã£ãŠããããšãããã£ãŠããŸããïŒ
ããã¢ãŒã¿ãŒé åïŒã©ã®éºäŒåãâãã€âçºçŸããããã®æä»€æ
ãšã³ãã³ãµãŒïŒãµã€ã¬ã³ãµãŒïŒéºäŒåã®ã¹ã€ããã調æŽããçºçŸã®åŒ·åŒ±ãã³ã³ãããŒã«
ã€ã³ããã³ïŒéºäŒåå éšã®éã³ãŒãé åïŒïŒ1ã€ã®éºäŒåããè€æ°ã®ã¿ã³ãã¯è³ªãçã¿åºãâå¯å€é åâ
ãã©ã³ã¹ããŸã³ïŒåãéºäŒåïŒïŒèªå·±ãè€è£œããŠã²ãã å ãâç§»åâãããåæ§ææ©æ§ã®æ ãæ
ãã³ã³ãŒãã£ã³ã°RNAïŒmiRNA, lncRNAãªã©ïŒïŒéºäŒåã®ç¿»èš³ãâæ¢ããâ圹å²ãæã€å¶åŸ¡åå
ããããéã³ãŒãé åã®æŽ»åã¯ããŸãã«âã³ãŒãã®èåŸã«ããå¶åŸ¡ã¢ã«ãŽãªãºã âãšåŒã¶ã¹ããã®ã§ãããããããã£ãŠãããåãèšèšå³ãâç¶æ³ã«å¿ããŠâ倿§ãªè¡šçŸãå¯èœã«ããã®ã§ãã
â ãšããžã§ããã£ã¯ã¹ãšâç°å¢ãšã®å¯Ÿè©±â
DNAãèšèšå³ã§ãããªãã°ããããâã©ãèªããâãšããèªã¿æ¹ã®ã¹ã¿ã€ã«ãããŸãã«ãšããžã§ããã£ã¯ã¹ã§ãã
ãã®èŠç¹ããã¯ã以äžã®ãããªããšãèŠããŠããŸãïŒ
åãéºäŒåãæã£ãŠããŠããè²ã£ãç°å¢ã»é£ç掻ã»ç²Ÿç¥ç¶æ ã«ãã£ãŠçºçŸããéºäŒåã¯å€ãã
ã¡ãã«åã»ãã¹ãã³ä¿®é£Ÿãªã©ã®ãæžã蟌ã¿ãã¯ãDNAé åãå€ããã«ã¹ã€ããã®ãªã³ã»ãªããæäœ
ã¹ãã¬ã¹ããã©ãŠãããæ°äžä»£ã«æž¡ã£ãŠãšããžã§ããã£ãã¯ã«ç¶æ¿ãããã±ãŒã¹ã
ã€ãŸããDNAã®éã³ãŒãé åã¯ç°å¢ããã®ä¿¡å·ã翻蚳ããè¡åãã¿ãŒã³ãå ç«åå¿ããå€åãããâ察話æ©èœâãæ ã£ãŠããå¯èœæ§ãããã®ã§ãã
â æ²é»ã¯æŠç¥ãïŒââå©å·±çéºäŒåã®èŠç¹ããèŠãéã³ãŒãé å
ãã®èŠç¹ãããã«æšãé²ããã®ãããªãã£ãŒãã»ããŒãã³ã¹ããå©å·±çãªéºäŒåãã§æç€ºããèŠæ¹ã§ãã圌ã«ããã°ãç§ãã¡ã®é«ã¯ãéºäŒåãèªå·±ãè€è£œãç¶ããããã®âä¹ãç©ïŒãŽã£ãŒã¯ã«ïŒâã«éããªããšããã®ã§ãã
ããæããã°ãéã³ãŒãé åââããªãã¡ãžã£ã³ã¯ãšãããŠããDNAââã¯ãåã«â䜿ãããŠããªãæ å ±âã§ã¯ãªããå°æ¥ã®ç°å¢å€åãçš®ã®åç¶ã«åããŠâç ãããŠããæŠç¥çè³ç£âãªã®ãããããŸããã
ãä»ãã«ã¯æå³ããªããŠããããã€ããã«åããŠéºäŒåãä¿ã£ãŠããâæ²é»âã
ããã¯ãèªå·±ä¿åãšç¹æ®ãšããéºäŒåã®é·æçæŠç¥ã®äžéšãšããŠçè§£ããããšãã§ããã®ã§ãã
â ç¡é³ã®äžã®ç§©åºââæå³ã¯âåšãâã®ãâçãŸããâã®ãïŒ
å²åŠçèŠç¹ã§èŠãã°ããžã£ã³ã¯DNAãšã¯ããŸã èªããªãæå³ã®ãããŸãããšãèšããŸãã鳿¥œã«ãããâäŒç¬ŠâããæåŠã«ãããâè¡éâãæ¥æ¬æåã§èšãã°âéïŒãŸïŒâã®ãããªåœ¹å²ã§ãã
ãã®æªè§£èªã®é åã瀺ããã®ã¯ã
ãæå³ã¯ã³ãŒãã ãã«å®¿ãã®ã§ã¯ãªãã
ãæèãæéããªãºã ãæ²é»ã«ããæå³ãããã
ãæå³ãšã¯ãçºçŸãããšãã«çãŸããâé¢ä¿æ§âãã®ãã®ã§ããã
ãšãããæ°ããçç©åŠççè§£ã§ãã
ã€ãŸããDNAã®97%ã¯âæ©èœããªãâã®ã§ã¯ãªããâéãã«æ©èœããŠããâã®ãããããŸããããããããã¯ãæ°å幎åŸã«çºçŸããå¯èœæ§ããããâæªæ¥æåã®æ å ±âãå å ããŠãããšãèããããã®ã§ãã
ç§ãã¡ã¯ãããããâèªãã3%âãè§£èªãã¯ãããã ãã
æ®ã97%ã¯ãå®å®ãç§ãã¡ã«é ããâæªèªã®å¡æºâãããããªãã
第3ç« ïŒç¥ã®é åã«èžã¿èŸŒãç§åŠ
â éºäŒåç·šéã®å ãšåœ± â
21äžçŽã«å ¥ã£ãŠãããçåœç§åŠã¯å é床çãªé²åãéããŸããããã®è±¡åŸŽçãªæè¡ããCRISPR-Cas9ïŒã¯ãªã¹ããŒã»ãã£ã¹ãã€ã³ïŒã«ä»£è¡šãããéºäŒåç·šéããŒã«ã§ãã
ããã¯ãDNAã®ç¹å®é åãçã£ãŠåæããæå³éãã«æžãæããããšãå¯èœã«ããããŸãã«âçåœã®ããã°ã©ãã³ã°âãšããã驿°ã§ããã
â ç ãæ²»ãåžæãšããŠã®ãå ã
éºäŒåç·šéæè¡ã¯ãããšããšé£ç ãéºäŒæ§çŸæ£ã«å¯Ÿããæ²»çãç®çãšããŠçºå±ããŠããŸããã
çãŸããªããã«ããŠæã£ãŠããéºäŒåç°åžžããæ£åžžãªé åãã«æ»ãããšã§çç¶ãæ ¹æ¬çã«æ¹åã§ãã
äŸãã°ãéç¶èµ€è¡ççãéºäŒæ§å ç«äžå šçãçãžã¹ãããã£ãŒãªã©ãåŸæ¥ã®æ²»çã§ã¯éçã®ãã£ãé åã§ææãäžãã€ã€ãã
ç现èã®DNAä¿®åŸ©æ©æ§ã«ä»å ¥ããããæ²»çãžã®å¿çšãé²è¡äž
確ãã«ããã¯ãçåœç§åŠã人é¡ã«ããããæ©æµã®è±¡åŸŽãšãèšãã鲿©ã§ãã
ãããããã®äžæ¹ã§ããã®æè¡ãéããæã¯ã決ããŠâæ²»çâã ãã«ãšã©ãŸããªãæ·±é ãªåããæããããŠããŸããã
â ãæžãæãããããšã®å²æ ¢
DNAã¯ãåãªãããŒã¿ã§ã¯ãããŸãããããã¯ãäœåå幎ã«ããããé²åã®ç©å±€ãšç°å¢é©å¿ã®èšé²ã§ãããããçš®ã®æŽå²æžã§ããããŸãã
ããã人éããâéœåã®ããããã«âæžãæãããšããè¡çºã¯ã
æèãããããã«å€ä»£ææžã®äžç¯ãæ¹å€ãããããªè¡çº
æãçŽã®ä»çµã¿ãç¥ããã«ãè€éãªæ§é ã®æãç®ãâåãåã£ãŠâããŸããããªãã®
èŠããŠããçŸè±¡ã ãã«åå¿ããå šäœæ§ãæé軞ã®é£ç¶æ§ãç¡èŠããå±éºãªè©Šã¿
ããšãæè¡çã«æåãããšããŠããããã«ã¯â人ç¥ã®éçâãšããå£ãåžžã«æšªããã£ãŠããã®ã§ãã
â äžä»£ãè¶ ãããäžå¯éæ§ã
ãšãããåé¡ã«ãªãã®ã¯ãçæ®çŽ°èïŒåµåã»ç²ŸåïŒãžã®ç·šéã§ããããã¯ããã®ãŸãŸæ¬¡äžä»£ã«éºäŒããïŒäººé¡ã®ã²ãã ãæžãæããããšãæå³ããŸãã
åã©ãèªèº«ã®åæãååšããªããŸãŸãèšèšããã人éããèªçãã
ç®çãâçŸæ£æ²»çâã§ãã£ãŠãããã®å»¶é·ç·äžã«èœååäžã»å®¹å§¿éžå¥ã»æ§æ Œæ¹å€ãšãã£ãé åãåŸ ã£ãŠãã
äžä»£ãè¶ ããå¯äœçšãéºäŒåãããã¯ãŒã¯ã®åŽ©å£ãªã©ãé·æç圱é¿ã¯èª°ã«ãäºæž¬ã§ããªã
ã€ãŸããéºäŒåç·šéã¯ãäžåºŠå§ããŠããŸãã°âæ»ããªãâæäœã§ãããã®ã§ãã
â ãã³ãã©ã®ç®±ã¯ãã§ã«éããŠããã®ãïŒ
2018幎ãäžåœã§äžçåã®éºäŒåç·šéãããŒãèªçãããšãããã¥ãŒã¹ãäžçãé§ãå·¡ããŸããããã®åŸãç ç©¶è ã¯åœéçéé£ã济ã³ãå«ççãªåé¡ã倧ããæµ®ã圫ãã«ãªããŸãããããã®åºæ¥äºã¯è±¡åŸŽçã§ãã
ç§åŠããã§ããããšããšããããŠè¯ãããšãã¯å¥ç©ã§ããã
å«çãšç§åŠãæè¡ãšå²åŠã
ãã®å¢çç·ãããŸããŸãææ§ã«ãªã£ãŠããçŸä»£ã«ãããŠãâ人éãã©ããŸã§èªç¶ã«ä»å
¥ãã¹ããâãšããæ¬è³ªçãªåããçªãã€ããããŠããŸãã
DNAãç·šéããããšã¯ãåãªãå»çè¡çºã§ã¯ãªãã
ããã¯ãååšã®å®çŸ©ã«èžã¿èŸŒãâå²åŠçè¡çºâã§ããã
第4ç« ïŒæ²é»ãšãã塿º
â âæ å ±ã®äœçœâãèªããã® â
ç§ãã¡ã¯ãæ
å ±ãšã¯ãã³ãŒãåãããæå³ãã®ããšã ãšæããã¡ã§ãã
ãAãTãGãCã
DNAã«äžŠã¶4ã€ã®å¡©åºããŸãããŸãã§æç« ã®ããã«ãæå³ãäŒããèšèªããšããŠè§£éãããŠããŸããã
ããããçåœã圢ã¥ãããã®æ ¹å¹¹ã«ã¯ãâèªãããªãâéšåãããªãã¡âæ²é»âãããæå³ãæã€ãšãããããäžã€ã®æ¬¡å ãååšããŠããã®ã§ã¯ãªãã§ããããã
â æ å ±ã¯âåšãâã ãã§ã¯æå³ã«ãªããªã
ä»®ã«ããã¹ãŠã®éºäŒåé åããæå³ãããã®ãã ã£ããšããŠããããããã©ã®é çªã§ãã©ã®ã¿ã€ãã³ã°ã§ãã©ã®æèã§è¡šçŸããããããªããã°ãçåœã¯æç«ããŸããã
ãã®æ§æã»æèã»ãªãºã ãäœããã®ããããéã³ãŒãé åã§ãããã空çœãããéïŒãŸïŒããªã®ã§ãã
DNAã®äžã§ãäžèŠã©ã³ãã ã«èŠããç¹°ãè¿ãé åïŒãµãã©ã€ãDNAïŒãã€ã³ããã³ã¯ãæé軞ã®âã¯ãã·ã§ã³âãšããŠæ©èœããŠããå¯èœæ§ããã
鳿¥œã«ããããäŒç¬Šãã®ããã«ãããããªããã°ç§©åºã厩ãã衚çŸãšããŠæãç«ããªããªã
ããã«ã転åå åãã©ã®ã¿ã€ãã³ã°ã§ãã®é åã«çµåãããã«ãã£ãŠããŸã£ããç°ãªãçµæãçãŸãã
ã€ãŸããçåœãšã¯âèªãããæå³âãšâèªãããªãã£ãäœçœâãšã®åå¥ã«ãã£ãŠåããŠåœ¢ãæããã®ãªã®ã§ãã
â èªã¿æã®ååšãâæå³âãçã
æ å ±ãæ å ±ãšããŠåãã«ã¯ãããããèªã¿è§£ãååšããå¿ èŠã§ããããšãã°ãéºäŒåã®é åã¯ãRNAããªã¡ã©ãŒãŒãšããååãâèªãâããšã§åããŠçåœåå¿ãçã¿åºããŸãã
ããã«ãçåœãšã¯äžæ¹åçãªåœä»€ã§ã¯ãªããâåæ¹åã®é¢ä¿æ§ã®äžã«ããçŸè±¡âã ãšããèŠç¹ãæµ®ãã³äžãããŸãã
æå³ã¯ãæžããããã®ã ãã§ãªãããããèªãŸãããšãã«ç«ã¡äžãã
æ²é»ããŸãããèªãŸããããšããåæã«ãããã«çœ®ãããŠãã
ãããŠãã®âé¢ä¿æ§âã¯ãæéãšç°å¢ã«ãã£ãŠå€åããåçæ§é ã§ãã
ã ãããããéã³ãŒãé åã¯ããã ã®æ²é»ã§ã¯ãªããâå¯èœæ§ã®ä¿çâãâæªæ¥ã®ããã®äœçœâãšãèšããã®ã§ãã
â æ²é»ã«ã¯âä¿åâã®åããã
人é¡ããŸã èªããªãDNAé åã«ã¯ãéå»ã®æ å ±ãæªæ¥ã®éžæãç°å¢ãžã®æè»æ§ããããŠæªçºçŸã®èœåãæããããŸããŠãããããããŸããã
çºçŸãããç ãç¶ããéºäŒå
ç¹å®ã®ç°å¢æ¡ä»¶ã§ã®ã¿åãå§ããâäºåçæ å ±â
倪å€ã®çåœãæ®ããâèšæ¶âãšããŠã®é å
çŸä»£ç§åŠã§ã¯æå³ã¥ãã§ããªãâéèšèªçç¥æ§âã®çè·¡
ãããã¯ãã¹ãŠãä»ã¯èªãããªãâæ²é»âãšããŠååšããŠããŸããããããã®æ²é»ã¯ã厩ãããçŠãããå®ãããã¹ãâçåœã®äœçœâã§ããã®ãããããŸããã
æ²é»ãšã¯ã塿ºã®éå¯ã§ããã
çºããããªãèšèã®äžã«ãããçåœã®æ·±å±€ã¯å®¿ãã
第5ç« ïŒé²åãšã¯äœãïŒ
â éºäŒåã¯æªæ¥ãæºåããŠããã®ã â
DNAã¯ãç§ãã¡ã®é«ã圢ã¥ããèšèšå³ã§ãããšåæã«ãé²åã®å±¥æŽæžã§ããããŸãã30å幎ã«ããã¶çåœã®æŽå²ã®äžã§ã幟床ãšãªãç¹°ãè¿ãããç°å¢ã®å€åãçµ¶æ» ãé©å¿ããããŠåç¹æ ããã®ãã¹ãŠããDNAãšããâæ å ±ã®å ç©âã«å»ãŸããŠããŸããã
ããããåãªãèšé²åªäœã«ãšã©ãŸãããDNAã¯âæªæ¥ã«åããæ å ±ã·ã¹ãã âã§ããå¯èœæ§ã瀺åããã¯ãããŠããŸãã
â å¶ç¶ã®å€ç°ãå¿ ç¶ã®éžæ
é²åè«ã®åºæ¬æ§é ã¯ã·ã³ãã«ã§ãïŒ
DNAã®ã³ããŒäžã«çããã©ã³ãã ãªå€ç°
ãããçåãç¹æ®ã«æå©ã§ããã°ã次äžä»£ãžãšâéžæâãããŠæ®ã
æå©ã§ãªããã°ãæ·æ±°ãããŠæ¶ãã
ããããã®âå¶ç¶ãšå¿ ç¶âã®çµã¿åããã ãã§ã¯èª¬æããããªãé²åã®äºäŸãæ°å€ãååšããŸãã
çš®å šäœãç°å¢å€åã«âåããŠããâãã®ãããªã¿ã€ãã³ã°ã§ã®é©å¿
é·æéç ã£ãŠããéºäŒåãçªåŠãšããŠçºçŸããæ°ããåšå®ãè¡åããããã
åãéºäŒåé åããæèã®éãã«ãã£ãŠå šãç°ãªã圢質ã衚ã
ãããã¯ãDNAããã ã®ååçèšé²ã§ã¯ãªããæªæ¥ãèªãâäœçœâãâäœåâãå å ããŠããããšã瀺ããŠããããã«èŠããŸãã
â ãã©ã³ã¹ããŸã³ãšâé²åã®æºå宀â
DNAã«ã¯ãâãžã£ã³ãã³ã°ã»ãžãŒã³âãšåŒã°ãããã©ã³ã¹ããŸã³ïŒåãéºäŒåïŒãšããé åããããŸããããã¯ã²ãã å ãç§»åããããè€è£œãç¹°ãè¿ãããããããšã§ãçªç¶å€ç°ã®âçºç«ç¹âãæ ã£ãŠããååšã§ãã
éåžžã¯éãã«ç ã£ãŠããããã¹ãã¬ã¹ãç°å¢å€åã«ãã£ãп޻æ§åããã
å¿ èŠã«å¿ããŠã²ãã æ§é ãçµã¿æ¿ããæ°ããªçºçŸãã¿ãŒã³ãçæ
ããã¯ãŸãã§ãé²åã®ããã®âã·ãã¥ã¬ãŒã·ã§ã³ã«ãŒã âã®ãããªåœ¹å²
å¶ç¶ã«èŠããå€åã®è£åŽã«ã¯ãå®ã¯ãããããçšæãããŠããâ詊è¡ã®å Žâãããã®ãããããŸããã
â 誰ã®ããã®é²åãïŒââçãæ®ãã®ã¯éºäŒåã§ãã
ããŒãã³ã¹ã®éºäŒåäžå¿ã®é²åè«ã§ã¯ãé²åãšã¯ãçš®ã®ãããã§ããåäœã®ãããã§ããªãã âéºäŒåãããã«ããŠçãæ®ããâãšããèŠç¹ã«ç«ã£ãå€åã®èšé²ã§ãã
ã€ãŸããç°å¢ã«å¿ããå€ç°ãéžæã®æ°ã
ã¯ããã¹ãŠéºäŒåãšããæ
å ±ãâèªå·±ãè€è£œãç¶ããããâã®æŠç¥ã ãšããã®ã§ãã ãã®èгç¹ããèŠããšãDNAã®éã³ãŒãé åãçªç¶å€ç°ãçã¿åºããã©ã³ã¹ããŸã³ããããé²åãå
åãããããã®â詊è¡âãâäœçœâãšããŠèšèšããããå©å·±çãªéºäŒåã®äžé¢ã§ããå¯èœæ§ãæµ®ãã³äžãããŸãã
â éºäŒåã¯âéå»âã ãã§ãªãâå¯èœæ§âãèšé²ããŠãã
é²åãšã¯ãéå»ã®åºæ¥äºã®é£ç¶ã§ã¯ãªããæªæ¥ãžã®åãã§ããããšããèŠç¹ãåºããã€ã€ãããŸãã
äžèŠã«èŠããéºäŒåé åã¯ãæªæ¥ã®ç°å¢ã«å¯Ÿå¿ããããã«âä¿çâãããŠãããããããªã
DNAã®éã³ãŒãé åã¯ã**çŸåšã§ã¯æ©èœããªãããå°æ¥ã®æ¡ä»¶äžã§æŽ»æ§åããâäºåé åâãšããªããã
ãä»ã¯äœ¿ãããŠããªãããç¡æå³ããšããã®ã§ã¯ãªããããŸã 䜿ãããŠããªãããšæããããšãå¿ èŠ
ãã®èгç¹ããèŠããšãDNAã¯åãªãèšèšå³ã§ã¯ãªããæªæ¥ã®å¯èœæ§ãå å ããâçåœã®äŒç·âã§ãããã®ã§ãã
çåœã¯ãå¶ç¶ã«å·Šå³ãããŠããããã«èŠããŠã
å®ã¯âåãã®æ§é âãæã£ãŠããââ
第6ç« ïŒæ å ±ã®ç¥èæ§
â 人éã¯çåœã«è§ŠããŠããã®ã â
æ
å ±ãšã¯ãåãªãããŒã¿ãèšå·ã®éãŸãã§ã¯ãããŸããã
ãšãããDNAã®ããã«ãèªããè€è£œããç¶æ¿ããå€åã«å¿ããŠæ¯ãèããå€ããâçããæ
å ±âã«ã¯ãç§åŠçã«ã ãã§ã¯å²ãåããªããæ¬è³ªçãªç¥èãã宿ã£ãŠããããã«æããŠãªããŸããã
ããã¯ãŸãã§ããè§ŠããŠã¯ãªããªãçŠæžãã®ããã§ãããããããã¯ãèªãŸããããšãåæãšããŠå°å°ããã塿ºãã®ããã§ããããŸãã
â æ å ±ãšã¯âååšâãã®ãã®ã§ãã
çŸä»£ç©çåŠãéåæ å ±è«ã®åéã§ã¯ãããã®å®å®ã®ããããååšã¯âæ å ±âãšããŠèšè¿°å¯èœã§ããããšããç«å ŽãåºãŸãã€ã€ãããŸãã
ç²åã®ç¶æ ããšãã«ã®ãŒãéåéãã¹ãŠãâæ å ±â
æèãææ ã§ãããããçš®ã®æ å ±è¡šçŸã§ãããšãã仮説
ã€ãŸããååšïŒæ å ±ã§ããããæ å ±ã«æãå ããããšãã¯ããååšãã®ãã®ãå€è³ªãããããšãã«ã»ããªããªã
ãã®åæã«ç«ãŠã°ãéºäŒåç·šéãšã¯æ å ±ãæžãæããããšã§ã¯ãªããååšã®å®çŸ©ãã®ãã®ãæ¹å€ããè¡çºãšãèšããã®ã§ãã
â ãªã人ã¯ãè§Šããããªããã®ã
ç§åŠã¯ãæªç¥ãã«è§Šããããšãã人éã®æ ¹æºç欲æ±ã«ãã£ãŠé²åããŠããŸãããDNAãšããâç¥ã®çè·¡âã®ãããªæ§é ã«ã人éãæãå ããããªãæ°æã¡ãçè§£ã§ããŸãã
ãããããã§åãããã¹ãã¯ããã§ãããã©ãããã§ã¯ãªãã
ãæ¬åœã«è§ŠããŠãããã®ãªã®ãïŒããšããå«çã®åé¡ã§ãã
ç§åŠã¯äžèœã§ã¯ãªãããã®éçãèªãèšå®ã§ããªããšããæŽèµ°ãå§ãŸã
çåœãšããååšã¯ãäºæž¬ã§ããªãè€éæ§ïŒè€éç³»ïŒãæã£ãŠãããåçŽãªå æã§èªããªã
ããããã«ãDNAã®âæ§é âã§ã¯ãªããâååšâãšããŠã®éã¿ãåãæ¢ããå¿ èŠããã
ãã®åãã«åãåããã«æè¡ãé²ããããšã¯ãæ å ±ãã䜿ããã®ããšããèŠãªã岿 ¢ãã«ã€ãªãããŸãã
â ç¥è©±ãšå®æã«èŠãâè§ŠããŠã¯ãªãã¬ç¥â
å€ä»£ãããäžçåå°ã®ç¥è©±ã宿ã«ã¯ãè§ŠããŠã¯ãªããªãç¥æµããšããããŒããç¹°ãè¿ãç»å ŽããŸãã
æ§çŽèæžã®ãšãã³ã®åïŒç¥æµã®å®ãé£ã¹ã人éã¯ã楜åã远ããã
æ¥æ¬ç¥è©±ã®å€©å²©æžïŒç¥ã®é åãæŽãããšãã«ç§©åºã厩å£ãã
ã®ãªã·ã¢ç¥è©±ã®ãã³ãã©ã®ç®±ïŒç¥èãéããããšã§çœåãåºãã£ã
ãããã®ç©èªã¯ãæè¡çâã¢ã¯ã»ã¹âãå¯èœã«ãªã£ããšãã«ããã人éã®å é¢ãåããããšããèŠéã§ããããŸãã
â è¬èããšããç¥æ§
DNAã«æãå ãããšããè¡çºã«ã¯ãå«ççã«ãå²åŠçã«ããâç¥ã®é åâã«è§Šããéã¿ã䌎ããŸããã ãããããç§ãã¡ã«ã¯å¿ èŠãªã®ã§ãã
ç§åŠã®æŽèµ°ãæ¢ãã粟ç¥çãªãªãã©ã·ãŒ
ç¥èãæã¡ãªãããããããè¡äœ¿ããªã倿å
ãããŠãããããªããã®ã«å¯ŸããŠç«ã¡æ¢ãŸãè¬èããšããç¥æ§
æ å ±ã«è§Šãããšã¯ãååšã«è§Šããããšã
ååšã«è§Šãããšã¯ãèªåã®åšãæ¹ãåãããããšã
è£ç« ïŒéºäŒåãèªã2ã€ã®çŒå·®ã
â ããŒãã³ã¹ãšã ã«ãžãŒã®äº€å·®ç¹ â
DNAã¯æ
å ±ã§ãããèšèšå³ã§ãããèšæ¶ã§ããã
ãããããããã©ãèªãããã©ãæãããã«ãã£ãŠãçåœèгãã®ãã®ãå€ãã£ãŠããŸããçŸä»£ã®éºäŒåŠãèªãããã§ããã®ãµãã€ã®åèãé¿ããŠéãããšã¯ã§ããŸããã
ãªãã£ãŒãã»ããŒãã³ã¹ãå©å·±çãªéºäŒåã
ã·ãããŒã«ã¿ã»ã ã«ãžãŒãéºäŒå â 芪å¯ãªãæŽå²ã
ã©ã¡ãããéºäŒåãšã¯äœãïŒããšããæ ¹æºçåããæ±ããªãããå°éããå°å¹³ã¯å€§ããç°ãªããŸãã

â ããŒãã³ã¹ã®å·åŸ¹ãªãŸãªããïŒéºäŒåã¯èªå·±ä¿åããè£ çœ®ã§ãã
ããŒãã³ã¹ã¯ã1976幎ã®èäœãThe Selfish Geneãã®äžã§ãçåœçŸè±¡ã®äžå¿ãâéºäŒåã®èªå·±ä¿åâã«çœ®ããŸããã
ãç§ãã¡ã¯çåæ©æ¢°ã§ããââéºäŒåãèªããè€è£œããããã«äœãäžããä¹ãç©ãªã®ã ãã
ãã®éæ¿ãªäžç¯ã瀺ãã®ã¯ãçåœãåäœãçš®ã®èŠç¹ã§ã¯ãªããæ å ±ãã®ãã®ã®èŠç¹ã§æãããšãã倧èãªãã©ãã€ã ã·ããã§ããã
éºäŒåã¯å©å·±çã§ãã
åäœãè¡åã¯ãéºäŒåã®ç¹æ®æŠç¥ã®äžéšã§ãã
ãæ¯æ§ããååããå©ä»æ§ãããããéºäŒåã«ãšã£ãŠã®æŠç¥çéžæã«éããªã
ã€ãŸããçç©åäœã®åæªãæå¿ã®ãããªâ人éçæå³ã¥ãâãæããçåœãåççãªæ å ±æŠç¥ã®é£ç¶ãšããŠæãåºããã®ã§ãã
â ã ã«ãžãŒã®æž©ããªèŠç¹ïŒéºäŒåãšã¯æèã§ãããç©èªã§ãã
ããã«å¯ŸããŠã ã«ãžãŒã¯ãããŒãã³ã¹ã®ææ³ãæ¹å€ããããã§ã¯ãªããâå¥ã®è§åºŠããéºäŒåãç §ãããâãšããèªãéšã§ãã
ãéºäŒåã¯ãç§ãã¡ã®å®¿åœã§ãããè§£éã§ãããéžæã§ãããã
圌ã®èäœãéºäŒå â 芪å¯ãªãæŽå²ãã§ã¯ã
éºäŒåãšããâã³ãŒãâãã人éã®éåœãšã©ãé¢ãã£ãŠããã
ç§åŠãé²ãã«ã€ããŠã瀟äŒãå«çãã©ãæºãåããã
éºäŒåæ å ±ããæã«åžæãçã¿ãæã«å·®å¥ãæŽåãçãã æŽå²
ãšãã£ããå€å±€çã§åæ çãªèŠç¹ãèªãããŠãããŸãã
ã ã«ãžãŒã«ãšã£ãŠã®éºäŒåãšã¯ããæå³ãå®ãŸã£ãæ§é ãã§ã¯ãªããèªãŸãããã³ã«æå³ãç«ã¡äžããâç©èªçæ å ±âãªã®ã§ãã

ã ã«ãžãŒã¯ããºãŒã ã¢ãŠãããŠæµ®ãã¶æå³ã®é¢šæ¯ã
â ãµãã€ã®èŠç¹ãæ¶æ©ããããã«
ç§ãã¡ãä»ãDNAãèªãããšãããšããå¿ èŠãªã®ã¯âã©ã¡ããäžæ¹ãéžã¶ããšâã§ã¯ãªããèŠç¹ãè¡ãæ¥ããããšã®ã§ããæè»ããããããŸããã
éºäŒåã¯å©å·±çãããããªãã
ããããç§ãã¡ã¯ãã®æ å ±ã«âæå³âãèªã¿åããç©èªãäžããããšãã§ããååšã§ãããã
ç§åŠãšç©èªã
æ§é ãšæèã
å·éãšæ
ç±ã
ãã®äž¡æ¹ãæºããŠãç§ãã¡ã¯2ã¡ãŒãã«ã®èºææ§é ã®åã«ç«ã¡ç¶ããã®ã§ãã
æçµç« ïŒ2ã¡ãŒãã«ã®å¥è·¡
â èšé²ã§ãããäºèšã§ãããç¥ãã§ãã â
ãã£ã1ã€ã®çްèã«ã2ã¡ãŒãã«ãã®æ
å ±ãæããããŸããŠããã
ããã37å
åããã¹ãŠã®çްèã«ã³ããŒãããŠããã
ããã«èšãããæ
å ±ã®ãã¡ãè§£èªã§ããŠããã®ã¯ããã3%ã
æ®ã97%ã¯ããŸã æå³ããå®ãã§ãªãâæ²é»ã®å¡æºâã
ãã®äºå®ã®åã«ç«ã£ããšããç§ãã¡ã¯ãã ãé©ããã®ã§ã¯ãªãã
âçããâãšããææ
ã«è¿ãäœããæ±ããã«ã¯ããããŸããã
â DNAã¯èšé²ã§ãã
DNAã¯ãç§ãã¡ã®çåœã ãã§ãªããæ°åå幎ã«ãããé²åã®èšé²ãå å ããŠããŸãããã®é åã«ã¯ã倪å€ã®æµ·ã«çãŸããåå§çåœã®èšæ¶ãé žçŽ ã䜿ãå§ãã现èã®éžæãå°çã®ç°å¢å€åã«å¿ããŠçµã¿æ¿ããããæ§é ã®è·¡ãããã¹ãŠå»ãŸããŠããŸãã
ããã¯ãŸãã§ãçåœãšããåäºè©©ãç¶Žã£ãå·»ç©ã§ãã
ãããŠãç§ãã¡ãä»ããããŠçããŠãããšããäºå®ãããããã®èšé²ãâéåããªãã£ãâ蚌ã§ãããDNAãèªãç¶ãããèšèã§ããããšã瀺ããŠããŸãã
â DNAã¯äºèšã§ãã
DNAã®æ
å ±ã«ã¯ãä»ã¯å¿
èŠãšãããŠããªãâæªæ¥ã®èšèšå³âãæœãã§ããŸãã
ãã©ã³ã¹ããŸã³ããã³ã³ãŒãã£ã³ã°RNAãã€ã³ããã³é åâŠ
ãããã¯ä»ãã®ç¬éã«ã¯æ²é»ããŠããŠããããç°å¢æ¡ä»¶ãããäžä»£ã«ãããŠãç®èŠããå¯èœæ§ã®çš®ã§ããããŸãã
çåœãšã¯ãéå»ã®èšé²ãããšã«ãæªæ¥ãæºåããæ§é äœã§ãããDNAãšã¯ãããŸã èµ·ããŠããªãäœããããã§ã«æ±ããŠããâäºèšã®åšâã§ãããã®ã§ãã
â DNAã¯ç¥ãã§ãã
ãããŠäœããããDNAãšã¯ãçåœã®é£ãªããã®ãã®ã§ãã
芪ããåãžãåããå«ãžãæ°ãåããªãäžä»£ãçµãŠäŒããããŠãããã®èºææ§é ã¯ããã ã®æ
å ±äŒéã§ã¯ãªãããåœãã€ãªãæå¿ãã®è¡šçŸãšãèšããŸãã
ç ã«åãã芪ããå¥åº·ãªåœãé¡ã£ãŠåãæ±ãããšã
å·®å¥ãæŠäºã®æä»£ã«ãã£ãŠããåžæãèšããŠåœãå®ãç¶ããç¥å ãã¡ããããšã
DNAã¯ãçããŠã»ããããšããç¡èšã®ç¥ããšããŠã次ã®äžä»£ã«äŒããããŠããã®ã§ã
ç§ãã¡ã¯ããã®ç¥ãã®åä¿¡è ã§ããããŸã次ã®çºä¿¡è ã§ããããŸãã
èšé²ãšããŠã®éå»ãäºèšãšããŠã®æªæ¥ãç¥ããšããŠã®çŸåšã
DNAã¯ããã®ãã¹ãŠãå å ãã2ã¡ãŒãã«ã®å¥è·¡ãªã®ã§ãã
ç§ãã¡ã¯ããã®âç¥ã®æ§æâã«å¯ŸããŠãäœãåŠã³ãäœãæãã¹ããªã®ã§ãããããç§åŠã¯ãããè§£èªããããšããæè¡ã¯ãããæäœããããšããŸãããããããããããªããã®ãã«åºäŒã£ããšãã®äººéã®æ 床ãããããã®ææã®åæ Œãæ±ºããã®ãããããŸããã
DNAã«åãåããšããããšã¯ã人éãèªãã®ååšã«åãåããšããããšã
ãã®æ
ã¯ãŸã å§ãŸã£ãã°ããã§ãããã®çã®çãã¯ã次ã®äžä»£ããã©ããã®éºç£ãšåãåããã«èšãããŠããã®ãããããŸããã
çµã³ã«ä»£ããŠ
2ã¡ãŒãã«ã®å¥è·¡ã
ããã¯ãç§åŠçãªæ°åã«ãããªãã®ãããããŸããã
ããããããã«ç¥å
ãšæªæ¥ãç¥ãšæ³ããæ²é»ãšåžæãè©°ãŸã£ãŠãããšãããã
ç§ãã¡ã¯ããã®å¥è·¡ããæäœãããåã«ããæãããå¿ èŠãããã®ãããããŸããã
ãããŠéãã«ããåãçŽãã¹ããªã®ã§ãã
âãã®å¡æºã«ãç§ã¯ã©ãåãåãã®ãâãšã
åœç€ŸãµãŒãã¹ãšãããããnoteèšäºã®ã玹ä»
