US Patent 7879819 - Nanoparticle drug delivery for diabetes treatment

http://www.freepatentsonline.com/7879819.html

GP Medical has built a considerable patent portfolio for methods of using nanoparticles for drug delivery such as US Patent 7879313 which also issued this week. This patent includes more specific claims toward using nanoparticles to deliver anti-diabetic drugs. Claim 1 reads:

1. A method of treating diabetes in a subject, comprising

administering bioactive nanoparticles to said subject,

wherein said bioactive nanoparticles consist of a positively charged chitosan, a negatively charged organic compound, and at least one anti-diabetic drug,

wherein a shell portion of said nanoparticles is dominated by said positively charged chitosan, and

wherein a core portion of said nanoparticles is formed by electrostatically complexing the positively charged chitosan and said negatively charged.

US Patent 7867984 - Obesity treatment using nanoparticles

http://www.freepatentsonline.com/7867984.html

Polymeric nanoparticles have been investigated to facilitate drug delivery for many years. This latest patent from GP Medical teaches using nanoparticle delivery for appetite-suppressing hormones. Claim 1 reads:

1. A method of treating obesity in a subject in need thereof comprising

identifying a subject in need of treatment for obesity and administering bioactive nanoparticles to said subject,

wherein said nanoparticles consist of positively charged chitosan, a negatively charged substrate, and at least one appetite-suppressing agent,

wherein a shell portion of said nanoparticles is dominated by said positively charged chitosan, and

wherein said negatively charged substrate is at least partially neutralized with a portion of said positively charged chitosan in the core portion of said nanoparticles.

US Patent 7863258 - Nanoparticle cancer treatment

http://www.freepatentsonline.com/7863258.html

This patent teaches using nanoparticles for anti-cancer drug delivery in which chitosan enhances absorption. Claim 1 reads:

1. A method of treating a cancer in an animal subject comprising

administering nanoparticles consisting of an antineoplastic drug or anti-cancer therapeutic agent in effective amount to treat said cancer, positively charged chitosan, and a negatively charged substrate,

wherein a surface of said nanoparticles is dominated by the positively charged chitosan.

US Patent 7556826 - Chewable nanoparticle composition for drug delivery

http://www.freepatentsonline.com/7556826.html

This patent from GP Medical teaches a nanoparticle drug delivery system for oral administration of proteins or peptides and suitable for animal feeding. Claim 1 reads:

1. A chewable composition for feeding an animal subject comprising a filler substance and nanoparticles that are blended with said filler substance, said nanoparticles comprising:

a shell portion that is dominated by positively charged chitosan,

a core portion that contains negatively charged substrate,

wherein said negatively charged substrate is at least partially neutralized with a portion of said positively charged chitosan in the core portion,

wherein said substrate is PGA, and

at least one bioactive agent loaded within said nanoparticles.

US Patent 7291598 - Nanoparticles for insulin delivery

http://www.freepatentsonline.com/7291598.html

This patent from GP Medical and National Tsing Hua University discloses a chemical composition for nanoparticulate insulin delivery to treat diabetes. Claim 1 reads:

1. A method of treating diabetes of a patient comprising orally administering insulin containing nanoparticles with a dosage effective amount of said insulin to treat said diabetes, wherein at least a portion of said nanoparticles comprises chitosan substrate and poly(glutamic acid).