Wouter Meuleman

Wouter Meuleman

Co-Founder at Locium · Affiliate Associate Professor, UW

Biography

Wouter Meuleman is a computational biologist and co-founder of Locium, a company that designs and experimentally validates synthetic regulatory DNA for better gene therapies. He is also an Affiliate Associate Professor at the University of Washington.

For over twenty years, Wouter has worked at the intersection of genomics, machine learning and large-scale data analysis, with a focus on how the regulatory genome is organized and how that organization can be read, interpreted and engineered. Genome-wide maps of regulatory elements now span hundreds of human cellular conditions, but their scale and complexity limit routine use. Wouter develops computational and machine learning approaches that reduce this complexity while retaining the information that matters.

Before Locium, Wouter was a Principal Investigator at the Altius Institute for Biomedical Sciences (2016–2025). Prior to that, he did postdoctoral work at MIT and the Broad Institute. He obtained his PhD in Computational Biology from Delft University of Technology and the Netherlands Cancer Institute. In 2020, Wouter was the recipient of the NIH NHGRI Genomic Innovator Award.

Available for select part-time projects and short advisory engagements, in regulatory genomics (including scientific due diligence for investors) and in other data-intensive fields. Get in touch!

Interests
  • Computational Biology
  • Regulatory Genomics
  • Generative Models
  • Synthetic Regulatory DNA
  • Epigenomics
  • Machine Learning
  • Data Visualization
Education
  • Postdoctoral Associate, 2012-2016

    Massachusetts Institute of Technology

  • PhD in Computational Biology, 2012

    Delft University of Technology, NL

  • MSc in Computer Science, 2005

    Leiden University, NL

Research

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Synthetic DNA sequences
Data-driven design of context-specific regulatory elements
Annotated regulatory Index
Chromatin accessibility patterns across 700+ biosamples
Data saliency - epilogos
Information-theoretic analysis of chromatin state maps
Chromatin state maps
Epigenomic profiles of 100+ human cell types
Lamina Associated Domains
High-level chromosome folding and genome organization