Concept

Telomere

OpenAlex ID: C177336024

The Hallmarks of Aging

2013 · Carlos López-Otín, Maria A. Blasco, et al. · Cell · 14,946

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 · Nam W. Kim, Mieczyslaw A. Piatyszek, et al. · Science · 7,090

Hallmarks of aging: An expanding universe

2023 · Carlos López-Otín, Maria A. Blasco, et al. · Cell · 6,479

Telomeres shorten during ageing of human fibroblasts

1990 · Calvin B. Harley, A. Bruce Futcher, et al. · Nature · 5,750

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

2007 · Hashem B. El–Serag, K. Lenhard Rudolph · Gastroenterology · 5,415

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 · Andrea G. Bodnar, Michel Ouellette, et al. · Science · 4,975

Cellular senescence: when bad things happen to good cells

2007 · Judith Campisi, Fabrizio d'Adda di Fagagna · Nature Reviews Molecular Cell Biology · 4,436

Structure and function of telomeres

1991 · Elizabeth H. Blackburn · Nature · 3,596

Telomere measurement by quantitative PCR

2002 · R. M. Cawthon · Nucleic Acids Research · 3,491

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Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 · Carol W. Greider, Elizabeth H. Blackburn · Cell · 3,401

Human Aging: Usual and Successful

1987 · John W. Rowe, Robert L. Kahn · Science · 3,377

The complete sequence of a human genome

2022 · Sergey Nurk, Sergey Koren, et al. · Science · 3,123

Shelterin: the protein complex that shapes and safeguards human telomeres

2005 · Titia de Lange · Genes & Development · 3,055

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Accelerated telomere shortening in response to life stress

2004 · Elissa S. Epel, Elizabeth H. Blackburn, et al. · Proceedings of the National Academy of Sciences · 3,001

A DNA damage checkpoint response in telomere-initiated senescence

2003 · Fabrizio d'Adda di Fagagna, Philip M. Reaper, et al. · Nature · 2,819

A survey of telomerase activity in human cancer

1997 · J.W. Shay, S. Bacchetti · European Journal of Cancer · 2,792

Premature ageing in mice expressing defective mitochondrial DNA polymerase

2004 · Aleksandra Trifunovic, Anna Wredenberg, et al. · Nature · 2,735

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

2012 · Jeremy Schwartzentruber, Andrey Korshunov, et al. · Nature · 2,630

Hallmarks of Cellular Senescence

2018 · Alejandra Hernandez-Segura, Jamil Nehme, et al. · Trends in Cell Biology · 2,588

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Oxidative stress shortens telomeres

2002 · Thomas von Zglinicki · Trends in Biochemical Sciences · 2,523

Mammalian Telomeres End in a Large Duplex Loop

1999 · Jack D Griffith, Laurey Comeau, et al. · Cell · 2,449

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Quadruplex DNA: sequence, topology and structure

2006 · Sarah Burge, Gary N. Parkinson, et al. · Nucleic Acids Research · 2,411

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Creation of human tumour cells with defined genetic elements

1999 · William C. Hahn, Christopher M. Counter, et al. · Nature · 2,346

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 · R K Moyzis, J M Buckingham, et al. · Proceedings of the National Academy of Sciences · 2,345

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

2020 · Raffaella Di Micco, Valery Krizhanovsky, et al. · Nature Reviews Molecular Cell Biology · 2,262

Works count: 46,540

Citation count: 1,616,000