
é·å¯¿ã®ããªã»ã92ã寿åœãšéŠãã®äžæè°ãªé¢ä¿â€ãäžçæšæºã®å èŠãã¬ãŒãã³ã°ãšç«ã¡ã¯ã ãããã·ãã¢ã®å£ã
ç§åŠãå®èšŒãããªãããªãå èŠãã¬ãŒãã³ã°ããšã¯
ååã¯ãéŠããšå¯¿åœã®å æé¢ä¿ã®3ã€ããšããŠãããããããå€±ãææã«ã€ããŠã話ãããŸãããå
èŠã®äœäžã飿¬²æžéãæããé«éœ¢è
ãäžæ°ã«èŠä»è·ç¶æ
ãžãšé¥ããããã¬ã€ã«ã»ããããã®åŒãéã«ãªãããšããçæŽ»ã«çŽçµããåå®ãªãªã¹ã¯ã§ããã
ã錻ã®å©ãã寿åœãå·Šå³ããçç±ã¯åãã£ããã§ã¯ãäžäœã©ãããã°ããã®ãïŒãä»åããã¯ãããããå£åã¢ãŒãã«å ¥ããããã·ã¹ãã ãèªãã®æã§ãåèµ·åããããããã®å ·äœçãªè§£æ±ºçã«èžã¿èŸŒãã§ãããŸãã
ãã€ãŠãäžåºŠå€±ãããå èŠãè¡°ããå èŠç¥çµãå ã«æ»ãããšã¯éåžžã«é£ãããšãããŠããŸããããããè¿å¹Žãå»åŠçã§ãã®å¹æãå®èšŒãããäžççãªæšæºæ²»çãšããŠèªãããã€ã€ããç»æçãªã¢ãããŒãããããŸããããããå èŠãã¬ãŒãã³ã°ïŒå èŠãªãããªããŒã·ã§ã³ïŒãã§ãã
ãã®ãã¬ãŒãã³ã°ã®åºæ¬ã¯ããã€ãã®ãã¬ã¹ãã³å€§åŠã®ããŒãã¹ã»ãã³ã¡ã«ææããèæ¡ããéåžžã«ã·ã³ãã«ãªãã®ã§ããçšæããã®ã¯ãè³ã®ç°ãªãå èŠå容äœããã©ã³ã¹ããåºæ¿ããããã«éžã°ããã系統ã®ç°ãªãã4ã€ã®éŠããã®ãšãã»ã³ã·ã£ã«ãªã€ã«ïŒç²Ÿæ²¹ïŒã§ãã
ããŒãºïŒè±ç³»ïŒãã¬ã¢ã³ïŒæç©ç³»ïŒããããŒãã³ãïŒããŒãç³»ïŒãã¯ããŒãïŒã¹ãã€ã¹ç³»ïŒ
ãã®4ã€ã®ç²Ÿæ²¹ããã«ã®èãéããæ¯æ¥ãæãšæ©ã®2åããããããã®éŠãã10ç§ã15ç§éãã€ããªã©ãã¯ã¹ããŠæ·±ãå ãããã£ãããã ãã®ãã¬ãŒãã³ã°ã§ãã
ãã€ã³ãã¯ããã æŒ«ç¶ãšã«ãããå ãã®ã§ã¯ãªãããããã¯ã¬ã¢ã³ã®ãã³ãšããçœãããªéŠãã ããããã¯ããŒãºã®è¯ãããªéŠãã ããšãé ã®äžã§ãã®éŠãã®ã€ã¡ãŒãžãéå»ã®èšæ¶ã匷ãæèããæ³åããªããå ãããšã«ãããŸãã
人éã®ç¥çµã®äžã§ãäŸå€çã«çµ¶ããçãŸãå€ããç¶ããŠããå ç¥çµã®æ§è³ªãå©çšãã錻ããè³ïŒæµ·éЬãå çïŒãžã®äŒèµ°è·¯ãæèçã«ããããµãŒãžãããŠåæ§ç¯ããŠãããããããããç§åŠãå°ãåºããè³ãšéŒ»ã®ãããã³ã°æè¡ãªã®ã§ãã
ã¢ããã®éŠãã§å èŠèå¥èœåã»éææ§ãªã©ããææãªæ¹åããšããçµæã«
ã§ã¯ããã®ãã¬ãŒãã³ã°ã®å¹æã¯ã©ã®ããã«èšŒæãããã®ã§ãããããããã«ã€ããŠãå°ãæ¢ã£ãŠã¿ãŸãããã
ãã³ã¡ã«ææãã2009幎ã«çºè¡šããåæã®ä»£è¡šçãªèšåºç ç©¶ã§ã¯ãåå ïŒæååŸãå€å·åŸãç¹çºæ§ãªã©ïŒãåããå èŠé害ãæã€æ£è ã察象ã«ã4çš®é¡ã®éŠãïŒããŒãºãã¬ã¢ã³ããŠãŒã«ãªãã¯ããŒãïŒãæ¯æ¥ææ©2åå ããã¬ãŒãã³ã°ã12é±éïŒçŽ3ã¶æïŒå®æœããŸããã
ãã®ç ç©¶ã®ææã¯æ¬¡ã®éãã§ãããã¬ãŒãã³ã°ãè¡ã£ãã°ã«ãŒãã¯ãè¡ããªãã£ãã³ã³ãããŒã«ïŒå¯Ÿç §ïŒã°ã«ãŒããšæ¯èŒããŠãã«ãããèå¥ããèœåïŒã©ã®éŠããã©ããåœãŠãåïŒããã³å èŠã®éŸå€ïŒã©ãã ã埮éãªã«ãããæç¥ã§ãããïŒã«ãããŠãçµ±èšåŠçã«æ¥µããŠææãªæ¹åãèŠãããŸããããã®ç ç©¶ãæ©ã«ãå èŠãªãããªããŒã·ã§ã³ã®æå¹æ§ãäžçäžã«åºãèªç¥ãããããã«ãªããŸããã
è³ã®æ§é ãå€åããããšãåãã£ã
ãã®ãã¬ãŒãã³ã°ã®å¹æã«é¢ããããã«éèŠãªãšããã³ã¹ãšããŠãå
èŠãã¬ãŒãã³ã°ãã錻ãã ãã§ãªãããè³ã®æ§é ãã®ãã®ãç©ççã«å€åãããããšããäºå®ããæ©èœçç£æ°å
±é³Žç»åè£
眮ïŒfMRIïŒãªã©ãçšããè³ç»åç ç©¶ã«ãã£ãŠèšŒæãããŠããŸãã
ãã¬ãŒãã³ã°ãç¶ç¶ãã被éšè ã®è³ãè§£æãããšãããã«ããã®åæåŠçãè¡ããå çïŒãã ããã ãïŒãã®äœç©ãå¢å ããã ãã§ãªããèšæ¶ãåžããæµ·éЬããææ ãåžãã倧è³èŸºçžç³»ããããã«ã¯æèãåžããçŒçª©åé ç®è³ªããç¹ãç¥çµãããã¯ãŒã¯ã®çµåæ§ïŒã€ãªããïŒã匷åã»æ¡å€§ããŠããããšã確èªãããŸãããäžèšã§ãããšããè³é åã®ãããã¯ãŒã¯åŒ·åãã§ããããã¯ã錻ããã®å®æçãªåºæ¿ããè³ãçŽæ¥ãããµãŒãžããŠè¥è¿ãããæé«ã®ã¢ãããŒãã§ãããšãã匷åãªèšŒæ ã§ããã
ããã¹ãæ¹ãŸã§æµæ¢ã«ãªã
2010幎代以éã«ã¯ãå 霢ã«äŒŽãèªç¶ãªå
èŠäœäžããã¢ã«ããã€ããŒç
ãªã©ã®èªç¥çåé§æïŒMCIïŒè»œåºŠèªç¥é害ïŒã®æ£è
ã察象ãšããç ç©¶ãé²ããããŸãããé«éœ¢è
ããã®å
èŠãã¬ãŒãã³ã°ã5ã8ã¶æãšãã£ãé·æã§ç¶ç¶ããå Žåãå
èŠãã®ãã®ã®å埩ã«ãšã©ãŸãããèšèªã®æµæ¢æ§ããå
šäœçãªèªç¥æ©èœã®è©äŸ¡ã¹ã³ã¢ã«ãè¯ã圱é¿ãåãŒãå¯èœæ§ãè€æ°ã®ç¬ç«ããç ç©¶ïŒKonstantinidisãã2013幎ãªã©ïŒã§å ±åãããã®ã§ãã
ã«ãããæèçã«èå¥ããããšããè¡çºããè³ã®ãåé èãããæµ·éЬãã®è¡æµãä¿ãã现èã®è¡°ãã«ãã¬ãŒãããããããš(èªç¥æ©èœã®ç¶æã»æ¹åã瀺å)ããšããã³ã¹ãšããŠç€ºãããŠããŸãããã³ã¡ã«ææãã®ç ç©¶ã蚌æããã®ã¯ãã人éã®å èŠç¥çµãè³ã®ãããã¯ãŒã¯ã¯ãé«éœ¢ã«ãªã£ãŠããã§ããé©åãªå€éšåºæ¿ïŒæ£ããä¿¡å·ïŒãéãç¶ããããšã§ãå¯éçã«åŒãäžããåæ§ç¯ã§ããããšããäºå®ã§ããã
ãªãçŽ æŽãããæ¹æ³ãªã®ã«ãã·ãã¢ã®å£ãã«ã¶ã€ããã®ã
ãšããããããã»ã©ã·ã³ãã«ã§ããã€ç§åŠçãªæ ¹æ ãããäžçæšæºã®å
èŠãã¬ãŒãã³ã°ãªã®ã«ãããæ¥åžžã§å®è·µããããšãããšãæ¥æ¬ã®ã·ãã¢ã®å€ããå
±éã®ãé«ãå£ãã«ã¶ã€ãããéäžã§æ«æããŠããŸãããšãåãã£ãŠããŸããã
ãããžã¡ã³ãã®èгç¹ããèŠããšãç¶ç¶ãé»ãå£ã«ã¯äž»ã«æ¬¡ã®3ã€ããããŸãã
1ïŒãæ¯æ¥åãéŠãããã å
ãã ãããšããççãªé£œã
ãã³ã¡ã«ææã®ææ³ã§ã¯ãåã4çš®é¡ã®éŠããæäœã§ã3ã¶æããå幎以äžãæ¯æ¥ææ©æ¬ ãããå
ãç¶ããããšãæšå¥šãããŠããŸããæåã¯æ°é®®ã§æ¥œããåãçµããŠããæ°é±éãçµã€ãšã仿¥ããŸãåãäœæ¥ãâŠâŠããšã匷çãªãã³ããªåãšé£œãã襲ã£ãŠããã®ã§ãã
2ïŒã¢ãããªã€ã«ã®ãæ±ãã¥ããããšæéã®å£
å°ããªã¢ããã®å°ç¶ã4ã€çšæããæ¯æ¥ææ©ã1ç¶ãã€èãéããŠã¯éããéããŠã¯éããç¹°ãè¿ããæå
ãå°ãäžèªç±ã«ãªã£ãŠããã·ãã¢ããé¢åãªäœæ¥ãèŠæãªæ¹ã«ãšã£ãŠããã®ãèš8åããã«ã®èãåããŠééããããšããè¡çºãã®ãã®ããæ¥åžžã®å€§ããªããŒãã«ïŒãã£ããã®çš®ïŒã«ãªã£ãŠããŸãã®ã§ãã
3ïŒãå¹ããŠããã®ãåãããªãããšããäžå®ã®å£
å
ç¥çµã®ã¿ãŒã³ãªãŒããŒã«ã¯æéããããããããã¬ãŒãã³ã°ãå§ããŠãæ°æ¥ãæ°é±éã§åçãªå€åãçŸããããã§ã¯ãããŸãããããžãã¹ã«ãããæ°å€ç®¡çãšåãã§ãèªåã®çŸåšã®ãæ£è§£çãããå埩床ããç®ã«èŠããŠå¯èŠåãããªãããããæ¬åœã«ããããã£ãŠããŠæå³ãããã®ã ãããããšçå¿æé¬Œã«ãªããã¢ãããŒã·ã§ã³ãç¶æã§ããªããªã£ãŠããŸãã®ã§ãã
ããªã»ã1ïŒãŸãã¯ã1çš®é¡ã®éŠããããæ°è»œã«å§ãã
4çš®é¡ãå®ç§ã«æããããšããããŸãã¯å®¶ã«ãããæ°ã«å
¥ãã®ã¢ããããã³ãŒããŒè±ãææ©ã®ç®ãªã©ã身è¿ãªéŠã1ã€ããå§ããŠã¿ãŠãã ããããæ¯æ¥å¿
ã4ç¶ããšããããŒãã«ãäžããã ãã§ãç¶ç¶ã®ããããã¯å€§ããå€ãããŸããæ
£ããŠãããå°ããã€çš®é¡ãå¢ãããŠããã°ååã§ãã
ããªã»ã2ïŒã«ã¬ã³ããŒã«ãâ¯ããã€ããã ãã®èšé²ãã€ãã
ãå¹ããŠãããåãããªãäžå®ããžã®å¯ŸçãšããŠãæ£è§£çãå³å¯ã«èšé²ããå¿
èŠã¯ãããŸããããã¬ãŒãã³ã°ãè¡ã£ãæ¥ã«ã«ã¬ã³ããŒãã¹ããŒããã©ã³ã«ãâ¯ããã€ããã ãã®ãããç°¡åãªèšé²ç¿æ
£ãåãå
¥ããŠã¿ãŠãã ãããç©ã¿éãªã£ãâ¯ã®æ°ãã®ãã®ããç¶ç¶ã®å®æãšéææãæ¯ããŠãããŸãã
æ¥æ¬ãšè¥¿æ¬§ãéŠããžã®åãåãæ¹ã¯ããéã
äžçæšæºã®å
èŠãã¬ãŒãã³ã°ã¯ç¢ºãã«çŽ æŽããããã®ã§ããããããç°¡åã«æ¥æ¬ã®ã·ãã¢ã«å®çã§ããªãã®ã¯ãéŠãã«é¢ããæåçãªåå°ãæ¥æ¬ãšè¥¿æ¬§ã§ç°ãªãããšã«åå ãããã®ãããããŸãããããããã¡ãã£ãšæ¬è«ããå€ããŠãæ¥æ¬ã«ãããéŠããžã®åãåãæ¹ã®åé¡ç¹ãæããŠã¿ãããšæããŸãã
æ¥æ¬ã«ã¯å€ãããéŠéã®æåããããŸãããæ¥æ¬ã®éŠéã¯ãè¶éã»è¯éãšäžŠã¶æ¥æ¬äžå€§èžéã®äžã€ã§ãããéŠããå ããã®ã§ã¯ãªãããéŠãèãïŒèéŠïŒããšãã衚çŸãçšããããšã«ç¹åŸŽããããŸããããã¯ãéŠæšãèªãããããããªç¹çްãªéŠãã«è³ãæŸãŸãããšãã粟ç¥ã衚ããŠããŸãã
éŠéã®æŽå²ã¯6äžçŽé ã仿ãšãšãã«éŠæšãæ¥æ¬ãžäŒæ¥ããããšã«å§ãŸããŸãããã®åŸã平宿代ã«ã¯è²Žæãè¡£æãæçŽã«éŠãçãæãããè«ç©ïŒãããã®ïŒãæåãçºéããŸãããå®€çºæä»£ã«ã¯æŠå®¶ãå ¬å®¶ã®éã§èžéãšããŠäœç³»åãããçŸåšã®éŠéãæç«ããŸãã
éŠéã§ã¯ãæé«çŽã®éŠæšã§ããæ²éŠãäŒœçŸ ãå°éãã€æž©ãããã®åŸ®åŠãªéŠãã®éããå³ãããŸãããŸãããçµéŠïŒãã¿ããïŒããšãããéŠããèãåããéã³ãç«¶æãçºéããŸããããæºæ°ç©èªãã顿ã«ãããæºæ°éŠãã¯ããã®ä»£è¡šäŸã§ãã
éŠéã§éèŠãããã®ã¯ãéŠãã®åªå£ã§ã¯ãªãããã®åæ§ãå³ããããšãå¿ãéãã粟ç¥ãæŽããããšãèªç¶ãžã®æ¬æãå£ç¯æãæããããšã§ããã€ãŸããéŠéã¯æèŠã磚ãèžè¡ã§ãããšåæã«ã粟ç¥ä¿®é€ã®éã§ããããŸãã
ããã«å¯ŸããŠã西欧ã§ã¯éŠãã¯å€ããã身ã ããªã¿ã瀟亀æåãšæ·±ãçµã³ã€ããŠããŸãããç¹ã«17ïœ19äžçŽã®ãšãŒãããã§ã¯ãå ¬è¡è¡çãå ¥æµŽç¿æ £ã®éãããããäœèãåãããç®çããéŠæ°Žæåãçºå±ããŸããããã®åŸã¯ãéŠæ°Žãåæ§ãé åãæŒåºããèžè¡ãžãšçºå±ããçŸåšã§ã¯ãã¡ãã·ã§ã³ã®äžéšãšããŠåºã芪ããŸããŠããŸãã
æ¥æ¬ãšè¥¿æ¬§ã§ã¯ããã®ããã«éŠãã«å¯Ÿãã倧ããªã¹ã¿ã³ã¹ã®éãããããŸããããããŠããã®ã¹ã¿ã³ã¹ã®éãã«ç¡èªèŠãªãŸãŸ1980幎代åŸåã«ã€ã®ãªã¹ããã©ã³ã¹ãããã¢ãããã©ããŒããšç§°ããæåãæµå ¥ã90幎代ãã21äžçŽåé ã«ãããŠäžçš®ã®ããŒã ãäœãäžããŸããã
ã©ã®ããŒã ã䌌ããšããã¯ãããŸããã西欧ã¢ãããã©ããŒãæ¥æ¬ã§ããŒã ã圢æããææãããã©ããŒ(æ²»çæ³)ããšç§°ãã€ã€ãåŠè¡çãå»åŠçãªçè«åºç€ã¯ããŸã確ç«ããŠããªãã£ãã®ãäºå®ã§ãã
次åãã·ãã¢åãã®è³ã®ããã®éŠããã¬ãŒãã³ã°ã玹ä»ããŸãã
åèæç®
Hummel, T., et al. (2009). Effects of olfactory training in patients with olfactory loss. Laryngoscope, 119(3), 496-499. ïŒäžçæšæºã®å
èŠãã¬ãŒãã³ã°ã®å¹æãå®èšŒãããã³ã¡ã«ææã®ä»£è¡šçè«æïŒ
López-OtÃn, C., et al. (2023). The hallmarks of aging: An expanding universe. Cell, 186(1), 24-44.ïŒçæŽ»ç¿æ
£ã®ç¶ç¶çãªå€æŽããšããžã§ããã£ãã¯ãªä¹±ãããªã»ããããéèŠæ§ãè«ããåºæ¬è«æïŒ
Haehner, A., et al. (2013). Effects of olfactory training in patients with postinfectious olfactory loss. The Laryngoscope, 123(9), 2233-2237.
Kollndorfer, K., et al. (2014). Olfactory training induces connectivity changes in task-related brain networks. Frontiers in Human Neuroscience, 8, 432. ïŒãã¬ãŒãã³ã°ã«ãã£ãŠè³ã®ç¥çµãããã¯ãŒã¯ãåæ§ç¯ãããæ§åãfMRIã§èšŒæããè«æïŒ
Konstantinidis, I., et al. (2013). Olfactory training in ageing and Alzheimer's disease. European Archives of Oto-Rhino-Laryngology, 270(5), 1589-1595. ïŒé«éœ¢è
ããã³åæèªç¥çãªã¹ã¯å±€ã«å¯Ÿããå
èŠãã¬ãŒãã³ã°ã®æå¹æ§ãæ€èšŒããç ç©¶ïŒ
ãé·å¯¿ã®ããªã»ããããç¥ãããã寿åœãã远ããããŠãããã人éãšã¯äœãããšããåãã«è¡ãçãã
ãã®åããå°èª¬ãšãã圢ã«ããŠã¿ãŸããã
å·çã¯æ¢¶å²¡éã
6æ15æ¥ãããã现èã¯äºå幎ãã¿ãæŒããå
š16è©±ãæ¯æ¥1話ãã€å
¬éããŠããŸãã第1話å
¬éåŸã¯ãã¡ããããèªã¿ããã ããŸãã
#现èã¯äºå幎ãã¿ãæŒã