芪ã®è¬ãéªã ããŸåŒã«å¢ãããåŠæ¹ã«ã¹ã±ãŒããã®çœ ãå®¶æã®åœãå®ã"ãè¬æåž³"ã®æ¬åœã®äœ¿ãæ¹
å®å®¶ã«åž°ããã³ã«ã芪ã®è¬ãå¢ããŠããæ°ãããã
ããæããããšã¯ãããŸãããïŒ
ããŒãã«ã«äžŠã¶ãæ°ã
ã®è¬ã®è¢ã
ããããæã§ããããå€ã§âŠâŠãããã©ã£ã¡ã ã£ãããªã
ãšç¬ãèŠªã®æšªé¡ã
ããå»è
ãããåºããŠããªã倧äžå€«ãã
ããèªåã«èšãèãããŠã
æ·±ãèããã®ããããŠããã
å®ã¯ç§ãããã ã£ãã
ã§ãä»ã¯ãç
æ£è¬å€åž«ãšããŠæ¯æ¥ã®ããã«ã
å
¥é¢ããŠããæ£è
ããã®æåè¬ãäžã€ã²ãšã€ç¢ºèªããŠããã
ãâŠâŠãªããã®è¬ãåºãŠãããã ããïŒã
éŠãããããªããæåž³ãããã£ãŠãããšã
ããããšã«æ°ã¥ãã
è¬ãå¢ããŠãã人ã«ã¯ããã¿ãŒã³ãããã®ã ã
ãããŠãã®ãã¿ãŒã³ã¯ã
é«éœ¢ã®èŠªã ãã®è©±ã§ã¯ãªãã
è€æ°ã®ã¯ãªããã¯ã«éã人ãªãã
幎霢ã«é¢ä¿ãªãã誰ã«ã§ãèµ·ããããã
ãããããããããªãèªèº«ã«ã
ãã§ã«å§ãŸã£ãŠãããããããªãã
ãã®èšäºã¯ã
ãã æããããããšãç®çã§ã¯ãããŸããã
ãæ£ããæãããããã£ãã察åŠããŠã»ããã
ããæã£ãŠæžããŸããã
ãã®è¬ãæ¬åœã«ãç æ°ãã®ããã«é£²ãã§ããŸããïŒ
ãŸããç æ£ã§ããåºäŒããããªè©±ãããŸãããã
è¡å§ãé«ããªããå
ç§ã§ãã䜿ãããéå§è¬
ïŒã¢ã ããžãã³ãªã©ã®ã«ã«ã·ãŠã æ®æè¬ïŒãåŠæ¹ãããã
è¬ã¯ã¡ãããšé£²ãã§ããã
è¡å§ããŸããŸãèœã¡çããŠããã
ãšããããã°ããããŠãè¶³ããããããã«ãªã£ãã
ã幎ã®ããããªã
ãæè¿ãæ©ãéãæžã£ãããããªã
ããæããªãããå¥ã®ã¯ãªããã¯ãžè¡ãã
ãè¶³ãããããã§ãããšäŒããã
ããã§ãæåã®è¡å§ã®è¬ãããã¿ã®åå ã ãšæ°ã¥ãããã°ããã
ã§ããè€æ°ã®ã¯ãªããã¯ã«ããã£ãŠãããšãå»åž«ã¯ãã¹ãŠã®è¬ãææ¡ããããŠããªãããšãããã
çµæãããã¿ãåãããã®å©å°¿è¬ã远å ãããã
ä»åºŠã¯ãå€äžã«äœåºŠããã€ã¬ã«èµ·ããããã«ãªã£ãã
ã幎ã®ããã§ãèè±ã匱ããªã£ãã®ããªã
ç ããªãæ¥ãç¶ãããããã€ãå»ã«çžè«ããã
ç¡ç è¬ã远å ãããã
ãããŸã§èªãã§ãæ°ã¥ããŸãããïŒ
æåã®åºçºç¹ã¯ã
ãè¡å§ãé«ãããšãããã äžã€ã®åé¡ã ã£ãã
ãããä»ããéå§è¬ã»å©å°¿è¬ã»ç¡ç è¬ã®3çš®é¡ã«ãªã£ãŠãããã©ãããçç¶ã蚎ãããåŠæ¹ããããè¬ãã©ãããå»åž«ã¯çç¶ãæ¹åãããããã«åºããŠããã
ããããåŠæ¹ã«ã¹ã±ãŒãããšåŒã³ãŸãã
è¬ã®å¯äœçšããæ°ããç æ°ïŒãŸãã¯å 霢ã«ããçç¶ïŒããšåéãããŠãè¬ããããåãã®ããã«è¿œå ãããŠããçŸè±¡ã ã
ç¹ã«ãå
ç§ã»æŽåœ¢å€ç§ã»çŒç§ã»æ³å°¿åšç§âŠâŠãš
è€æ°ã®ã¯ãªããã¯ãå蚺ããŠããé«éœ¢è
ã»ã©ã
ãã®çœ ã«ã¯ãŸããããã
ããããã®å»åž«ããèªåã®å°éé åããèª å®ã«èšºãŠããã®ã«ãè¬å šäœã俯ç°ããŠèŠãŠãã人éã誰ãããªãããšããç¶æ³ãçãŸããããããã ã

ãããŠããã®ã«ã¹ã±ãŒãã«ã¯æ²æšãªçµæ«ãããã
ç¡ç è¬ã远å ããããã®å€äžã
ãã€ã¬ã«èµ·ããããšããç¬éã
ãµãã€ããŠè»¢åããã
ââ倧è
¿éªšéªšæã
å
¥é¢ããã®ãŸãŸå¯ããããžââã
ã幎ã®ããã§è»¢ãã ããšèšãããããšãå€ãã
ã§ãç§ã¯ããã®çµç·¯ãäœåºŠãäœåºŠãèŠãŠããè¬å€åž«ãšããŠãæèšãããã
ã幎ã®ãããã§ã¯ãªãã
æåã®è¡å§ã®è¬ããå§ãŸã£ã
ãè¬ã®ãããåãããåå ãããããªãã
ããã«æãã®ã¯ã
è
æ©èœãèœã¡ãŠãã人ã®å Žåã ã
è
èã®åãã匱ããªããšã
è¬ãããŸãææ³ãããäœå
ã«èç©ãã
ãéåžžéã®ã¯ããªã®ã«å¹ããããã
ãšããç¶æ
ã«ãªãã
ç¡ç è¬ãäœã«æºãŸãã°ã
ç¿æã«ãªã£ãŠãç æ°ããµãã€ããæ®ãã
転åãªã¹ã¯ã¯ãããã«è·³ãäžããã
ããã®è¬ã®éããããã®äœã«åã£ãŠãŸããïŒã
ãã®äžèšãã骚æãé²ãããšã«ã€ãªãããããããªãã®ã ã
ããããã©ãããã°ããã®ããçãã¯ã·ã³ãã«ã
ãåŠæ¹ã«ã¹ã±ãŒãããæã¡åãããã«ã
仿¥ããã§ããããšãããã
ããã¯ããè¬æåž³ã1åã«ãŸãšããããšã
ãããŠãè¬å±ã1ãæã«çµãããšã
æåæãããã»ã©å°å³ãªçãã ãšæã£ã人ã
ã¡ãã£ãšåŸ
ã£ãŠã»ããã
å»åž«ã¯ãèªåã®å°éé åã蚺ãããã ã
ã§ããããªããå¥ã®ã¯ãªããã¯ã§äœãåŠæ¹ãããŠããããããªã¢ã«ã¿ã€ã ã§ææ¡ããããšã¯é£ããã
ããã§ããä»ã¯ãã€ãã³ããŒã«ãŒãã§æ
å ±ããŸãšãŸãããã«ãªã£ãŠããããã以åããã¯ããã®ãããããªãã
ãšã¯ãããå»åž«ãå
šãŠãææ¡ããã®ã¯å€§å€ã
ã ãããããè¬ã®å
šäœåã俯ç°ã§ããååšãå¿
èŠã«ãªãããããããããã€ãè¬å€åž«ã ã
ãè¬æåž³ã1åã«ãŸãšãŸã£ãŠããã°ã
è¬å€åž«ã¯
ããã®è¬ãšãã®è¬ãå®ã¯çžæ§ãæªãã
ããã®çç¶ããããããŠè¬ã®å¯äœçšã§ã¯ïŒã
ãšæ°ã¥ãããšãã§ããã
ãè¬æåž³ã¯ã
ã·ãŒã«ã貌ãããã®ããŒããããªãã
ããªãã®èº«ãå®ããã¹ããŒãã ã

ã§ãããè¬æåž³ãåºãã ãã§ã¯ããŸã è¶³ããªãã
é岡çå¯å£«å®®åžã®ç
é¢ã»è¬å±ã§è¡ããã
ã¢ã³ã±ãŒã調æ»ïŒå°æããå¯å£«å®®åžç«ç
é¢è¬å€éšïŒã§ããããªçµæãåºãŠããã
ä¿éºè¬å±ã§è¬ãããã£ãããšãããæ£è 51åã®ãã¡ãèªåã®è æ©èœãè¬å±ã«äŒããŠãã人ã¯ãããã10åïŒ20ïŒ ïŒã
æ®ãã®80ïŒ ã¯ãäŒããŠããªãã£ãã
ã¢ã³ã±ãŒã調æ»ïŒå°æããå¯å£«å®®åžç«ç é¢è¬å€éšïŒ
ãè èãæªãããšããããã«ã«ããèŠãã°ãããããããªãã®ïŒã
ããæããããããªãã
ã§ãè¬å±è¬å€åž«ã¯ã
ç
é¢ã®ã«ã«ãã«ã¢ã¯ã»ã¹ã§ããªãã
åŠæ¹ç®ã«æžãããæ
å ±ãšã
ç®ã®åã®æ£è
ããã話ããŠãããããšã ããã
倿ææã®ãã¹ãŠã ã
è
æ©èœãäœäžããŠããããšãç¥ããªããã°ã
è¬å€åž«ã¯ãéåžžéãã§ç¢ºèªãçµããŠããŸãã
ããããèç©ã«ã€ãªããã
ãµãã€ãã«ã€ãªããã
転åã«ã€ãªããã
äŒããªããã°ãå®ãããšã¯ã§ããªããã§ãã
ãè èã®æ°å€ããäŒããã ãã§ãè¬å€åž«ã¯åãã
ãè¬æåž³ã1åã«ãŸãšããã
ãããã€ãè¬å±ã決ããã
ããããããæ¬¡ã«ãã£ãŠã»ããããšãããã
èªåã®è æ©èœïŒeGFRïŒãã
è¬å€åž«ã«äŒããããšã
eGFRãšã¯ã
è
èãã©ããããåããŠããããç€ºãæ°å€ã ã
è¡æ¶²æ€æ»ã®çµæçšçŽã«
ãeGFRããšæžããŠããã°ããããããã ã
ãã®æ°å€ãäŒããã ãã§ã
è¬å€åž«ã«ã§ããããšããŸã£ããå€ãã£ãŠããã
ç§ã¯ç
é¢è¬å€åž«ãªã®ã§ã
å
¥é¢æ£è
ããã®æ€æ»çµæã¯ãã€ã§ã確èªã§ããã
ããã§ãã
ãå
¥é¢åã®ãã®äººã®è
æ©èœãã¯ããããªãã
以åããããªæ£è
ãããããã
æ°å¹Žåã®è¡æ¶²æ€æ»ã§ã¯ã¯ã¬ã¢ããã³å€ã1.0ã1.2ã ã£ãæ¹ãã骚æåŸã«è»ããç¶æ
ã«ãªãã
å骚æããã£ããã«åœé¢ãžå
¥é¢ããŠããã
å ¥é¢æã®æ¡è¡ã§ã¯ã¬ã¢ããã³å€ã確èªãããšã0.5ããè æ©èœãåé¡ãªãã§ããããšäž»æ²»å»ã¯èšã£ãã
ã§ãç§ã¯ãåŒã£ããã£ãã
æ°å¹Žåã«1.0ã1.2ã ã£ã人ãããªã0.5ã«ïŒ
è»ããçæŽ»ã§çèéãèœã¡ãã°ã
ã¯ã¬ã¢ããã³ã®ç£çéèªäœãæžãã
ã€ãŸããæ°å€ã®äžã§ã¯ãæ£åžžã«èŠãããã ãã§ã
å®éã®è
æ©èœã¯ãã£ãšæªãå¯èœæ§ãããââã
ä»èŠããŠããæ°å€ã¯ã
æ¬åœã®ããšãèšã£ãŠããªããããããªã
ãã®ãã©ã°ãç«ãŠãããã®ã¯ã
éå»ã®æ€æ»å€ãšã®æ¯èŒããã£ãããã ã
è
æ©èœã®åœ¹å²ã¯ã
ãåŠæ¹ãããè¬ãå®å
šã«åºãããã«å¿
èŠãªæ°å€ãã ããããªãã
ãã®äººã®ããããŸã§ããšãããããããå®ãããã«å¿ èŠãªæ å ±ã ãšãç§ã¯ãã®ä»äºãéããŠå®æããŠããã
ð¡ ããããŠèªã¿ãã
ããå»è ãããããæ£åžžå€ãã£ãŠèšããããã倧äžå€«ããããå®å¿ããŠãã芪埡ããã®æ€æ»çµæãå®ã¯âèŠãããã®æ£åžžâãããããŸããã å¥åº·èšºæã®ãAå€å®ãã«é ãããé«éœ¢è ç¹æã®èœãšã穎ïŒãã¹ãã³ã°ïŒãšãæ¬åœã®è èã®å¯¿åœãç¥ãããã®ãeGFRãã®èªã¿è§£ãæ¹ãããã¡ãã®èšäºã§è©³ãã解説ããŠããŸãã
è æ©èœã®æ©èœãäœäžããŠããããšãäŒããæåŒ·ããŒã«ãããCKDã·ãŒã«ãã ã
CKDãšã¯æ
¢æ§è
èç
ã®ããšã
ãã®ã·ãŒã«ã«ã¯èªåã®è
æ©èœã®ã¹ããŒãžãæ°å€ãèšå
¥ã§ãããè¬æåž³ã«è²Œã£ãŠããããšã§ã
ã©ã®å»çæ©é¢ã§ãäžç®ã§è
æ©èœãææ¡ããŠããããä»çµã¿ã ã
ãã ãã誰ã§ããã®å Žã§ããããã·ãŒã«ã§ã¯ãªãã
è
æ©èœã®å€ãç¶æ
ãããšã«ã
å»åž«ãè¬å€åž«ãããã®æ¹ã«ã¯å¿
èŠããšå€æããããã§è²Œããã®ã ã
ãŸã äžè¬ãžã®èªç¥ãåºãã¯ãªãã
ç¥ããªãå»çè
ãããã
æ¯èŒçæ°ããåãçµã¿ã§ãããã
ãèªåã¯è
èç
ã§ãã£ãŠå®£èšããã¿ããã§å«ã ã
ãšæãæ¹ããããããããŸããã
ã§ããå®å¿ããŠãã ããã
ããã¯ç
æ°ã®ã¬ããã«ã貌ããã®ã§ã¯ãªãã
ãããªãã®è
èã®åãã«åãããŠè¬ã®éã調æŽãã
å¯äœçšããäœãå®ãããã®ãå®ãããªãã§ãã
ã ãããæ¥ããããããã«ã·ãŒã«ãããã£ãã貌ã£ãŠã»ããã
è¬å±ãç
é¢ã®çªå£ã§èŠããŠã»ããã
ãã®è¡åããè
æ©èœãäžç·ã«ç¢ºèªãããã£ããã«ãªãã

ãããŠãã®ã·ãŒã«ãèŠãè¬å€åž«ãäœããããã
ç¥ã£ãŠã»ããã
åŠæ¹ãããè¬ã®éãã
è
æ©èœã«åãããŠèšç®ãçŽãã
ããã®æ°å€ãªãããã®è¬ã¯äœã«èç©ããŠå±ãªãããšå€æãããââåŠæ¹ããå»åž«ã«çŽæ¥é»è©±ããããã
ãè
æ©èœãäœäžããŠããã®ã§ããã®è¬ãåéã«æžãããŸãããïŒã
ãããç矩ç
§äŒãšããã
è¬å€åž«ã¯ãè¬ãè¶³ãã ãã®ä»äºãããŠããªãã
åŒãç®ãææ¡ããèšç·ŽããåããŠããã
ããšãã°ãé«éœ¢è
ããã飲ã
ãèè¬ïŒãã¡ã¢ããžã³ãªã©ïŒãã
ãã¢ã«ããã€ããŒã®è¬ãã
è
èãæªã人ãããããéåžžéã§é£²ã¿ç¶ãããšã
äœã«èç©ããŠã匷ãç æ°ãåºããã
ãµãã€ããŠè»¢åããŠããŸã£ããããŸãã
CKDã·ãŒã«ãèŠãè¬å€åž«ã¯ã
ããã«æ°ã¥ããŠå»åž«ã«é»è©±ããããŸãã
ãè æ©èœãäœäžããŠããã®ã§ã
ãã®èè¬ã¯åéã«æžãããŸãããïŒã
ãããã£ãŠãæ°ã¥ããªããã¡ã«èµ·ããŠããâè¬ã®å¯äœçšïŒãµãã€ããç æ°ïŒâããåŒãç®ã«ãã£ãŠæªç¶ã«é²ãã®ã§ãã
仿¥ãè¬ç®±ãéããŠã¿ãŠã»ãã
ä»åºŠå®å®¶ã«åž°ã£ããã
芪ã®ãè¬æåž³ãäœåã«ãåãããŠããªããã
確èªããŠã¿ãŠã»ããã
ãããã¯ä»æ¥ãèªåã®è¬ç®±ãéããŠã¿ãŠã»ããã
ããªãã§ãã®è¬ã飲ã¿å§ãããã ã£ãïŒã
ãšéŠãããããè¬ãäžã€ã§ããã£ãã
ââããããèŠçŽãã®ãµã€ã³ãããããªãã
ããããããã
å¯äœçšã®ãããåãïŒåŠæ¹ã«ã¹ã±ãŒãïŒãããã®ãããããŸããã
åŠæ¹ããŠãããå çã«èããªããŠãçã£ãŠãã¿ããã§âŠããããªããšã§ããªãã
ãã®æ°æã¡ãããããŸãã
ãããªãšãã¯è¬å±ã®çªå£ã§ãèããŠã¿ãŠãã ããã
ãè¬ãããããå¢ããŠå¿é ã§ãã
ãå çã«ããã£ãè¡æ¶²æ€æ»ã®çµæãªãã§ãããèŠãŠããããŸããïŒã
ãã®äžèšããç§ãã¡è¬å€åž«ã¯åŸ
ã£ãŠããŸãã
æ€æ»çµæã®çŽããã®ãŸãŸãè¬æåž³ã«æãã§ã
æã£ãŠããŠãããã ãã§ãããã
éå»ãšä»ã®æ°å€ã䞊ãã§ããã°ããªãããã
åŠæ¹ã«ã¹ã±ãŒãã¯ãæ°ã¥ãã人ããæã¡åããŸãã
芪ãå®ããããšæã£ãŠèªã¿å§ããããªããã
èªåèªèº«ãå®ãã人ã«ãªããŸãããã«ã
æåŸã«äžã€ã ãã
远å ã§ç¥ã£ãŠãããŠã»ããããšããããŸãã
åŠæ¹ã«ã¹ã±ãŒãã§è¬ãéªã ããŸåŒã«å¢ããçµæã
ãã€ã®éã«ããè¡å§ã®è¬Ãå©å°¿è¬Ãçã¿æ¢ãããšããçµã¿åããã宿ããŠããŸãããšããããã§ãã
ãã®äžã€ãæã£ããšãã
è
èã«ã¯ææªã®äºæ
ãèµ·ããã
ãã®çµã¿åããã«ã¯
ãããªãã«ã¯ãŒããŒããšããååãã€ããŠããŸãã
èªåã芪ã飲ãã§ããè¬ã®äžã«ã
ãã®äžã€ãæã£ãŠããªãã
ââãã²ç¢ºèªããŠã¿ãŠã»ããã
âŒããããŠèªã¿ãã
ãããªãã«ã¯ãŒããŒãã®è§£èª¬èšäºã¯ãã¡ãã
ãã®èšäºãåèã«ãªã£ããšæãããã
ãã²ã¹ããã³ã¡ã³ãã§æããŠãã ããã
ããã¡ã®èŠªãããããã
ãèªåã®è¬æåž³ãèŠçŽããŠã¿ãŸãã
ââãããªäžèšããæ¬¡ã®èšäºãæžãåã«ãªããŸãã
åèæç® å°æè±ã»é£¯å¹²èã»æž¡éåæããæ£è ãšè¬å±è¬å€åž«ã察象ãšããCKDã·ãŒã«ã«ããè æ©èœæ å ±å ±æã®æçšæ§ã«é¢ããã¢ã³ã±ãŒã調æ»ãå¯å£«å®®åžç«ç é¢è¬å€éšã»ã
https://www.jstage.jst.go.jp/article/jjnp/10/3/10_347/_pdf/-char/ja
ð ç
é¢ã®è¬ã ããããªãããã©ãã°ã¹ãã¢ã«ãæœãçœ
ãããŸã§èªãã§ãã ãã£ãæ¹ã¯ã
ãã£ãšãèªèº«ããå®¶æã®å¥åº·ãçå£ã«èããŠããæ¹ã ãšæããŸãã
ãè¬æåž³ã§ç é¢ã®è¬ã管çã§ããŠãããäœã«è¯ãããã ããããšèŠªãåæã«è²·ã£ãŠãããµããªã¡ã³ãããé¢šéªæ°å³ã®ãšãã«é£²ãåžè²©è¬ãã匱ã£ãè èã«èŽåœçãªãã¡ãŒãžãäžããããšãå€ã ãããŸãã
ããããããã©ãã°ã¹ãã¢ã§äœãéžã¹ã°ããã®ïŒã
ã芪ã飲ãã§ãããã®ãµããªã¯å®å
šïŒã
çŸå Žã§æ°ã
ã®ãã€ãªããããèŠãŠããç
æ£è¬å€åž«ã®èŠç¹ããã
ãèªåã®èº«ãå®ãããã®åžè²©è¬ã»ãµããªã®æ£ããéžã³æ¹ãã以äžã®èšäºã«ãŸãšããŸããã
倧åãªãå®¶æã®è
èãå®ãæãããã«ã
ãã²ãã¡ããããããŠãèªã¿ãã ããã
ãããªãšæã£ããå¿æŽãããïŒ
ãããããã°å¿æŽãé¡ãããŸãïŒããã ãããããã¯ãªãããã³Cã®è³Œå
¥è²»ãšããŠã¢ãããŒã·ã§ã³ãšæŽ»åã¢ããã«äœ¿ãããŠããã ããŸãâš