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Shotgun sample sequence comparisons between mouse and human genomes

Nature Genetics volume 25, pages 31–33 (2000) Cite this article

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Abstract

A mixed ‘clone-by-clone’ and ‘whole-genome shotgun’ strategy will be used to determine the genomic sequence of the mouse. This method will allow a phase of rapid annotation of the contemporaneous human sequence draft, through whole-genome ‘sample sequence comparisons’.

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Figure 1: Comparison of random shotgun reads from the mouse genome with human sequences rapidly identifies regions of potential biological importance.

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Acknowledgements

J.B., M.M. and R.G. are supported by grant number HG02139 from the National Human Genome Research Institute at the National Institutes of Health.

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Authors and Affiliations

  1. Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030, Texas, USA

    John B. Bouck, Michael L. Metzker & Richard A. Gibbs

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  1. John B. Bouck
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  2. Michael L. Metzker
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  3. Richard A. Gibbs
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Corresponding author

Correspondence to John B. Bouck.

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Bouck, J., Metzker, M. & Gibbs, R. Shotgun sample sequence comparisons between mouse and human genomes. Nat Genet 25, 31–33 (2000). https://doi.org/10.1038/75563

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