File:Substrate-targeting sites on cyclin–Cdk complexes.pdf
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Substrate-targeting sites on cyclin–Cdk complexes
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English: The central substrate-recognition site on Cdks lies in the active-site T-loop, which interacts with the SPXK consensus sequence that contains the phosphorylation site (see Figure 3-12). An RXL motif in some substrates interacts with the hydrophobic patch on the cyclin, thereby enhancing the rate of phosphorylation. The presence of a phosphate-binding pocket on the accessory subunit Cks1 may facilitate interactions with targets that contain multiple phosphorylation sites.[1] |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248297/ |
| Author | David O Morgan |
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| current | 01:47, 8 April 2020 |  | 1,425 × 1,356 (920 KB) | Rob Hurt (talk | contribs) | Uploaded a work by David O Morgan from The Cell Cycle. Principles of Control. with UploadWizard |
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