3D render of a dense network of neurons on a white background

Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more

The atlas of gene expression in the prefrontal cortex was created using samples from almost 1,500 donors of all ages — from infants to centenarians.

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  • Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have shaped the composition of human skeletal tissue.

    • Yizhi Yan
    • Nadav Mishol
    • David Gokhman
    ArticleOpen Access
  • Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data on outbreaks are currently limited by inequalities in healthcare access.

    • Rory Gibb
    • Sadie J. Ryan
    • Colin J. Carlson
    ArticleOpen Access
  • Multidecadal fluctuations in Earth’s length of day are shown to be driven by gravitational torque and resisted by electromagnetic and topographic forces, improving our understanding of the material properties and dynamics of Earth’s deep interior.

    • Huifeng Zhang
    • Mathieu Dumberry
    ArticleOpen Access
  • Single-nucleus transcriptomics across diverse populations is used to explore how genetic risk for brain disorders affects specific cell types, revealing previously hidden gene–trait associations and conserved, cell-type-specific mechanisms.

    • Sanan Venkatesh
    • Roman Kosoy
    • Panos Roussos
    ArticleOpen Access
Illustration showing  a neutron approaching an atomic nucleus in order to initiate a nuclear fission reaction. The nucleus is surrounded by orbiting electrons.

Nuclear power

Few scientific phenomena have been associated with such an eerie blend of menace and promise as nuclear fission.
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