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Kcnt1 Gene Detail
Summary
  • Symbol
    Kcnt1
  • Name
    potassium channel, subfamily T, member 1
  • Synonyms
    C030030G16Rik, Slack, slo2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924627
    NCBI Gene: 227632
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25753807-25808285 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 18.27 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1484 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924627
 protein coding gene Chr2:25753746-25808285 (+)
129S1/SvImJ ENSMUSG00200050790
 protein coding gene Chr2:22737925-22792467 (+)
A/J ENSMUSG00195046523
 protein coding gene Chr2:22828083-22881464 (+)
AKR/J ENSMUSG00220053334
 protein coding gene Chr2:22945909-22999294 (+)
BALB/cJ ENSMUSG00180053879
 protein coding gene Chr2:22839600-22894143 (+)
C3H/HeJ ENSMUSG00175053516
 protein coding gene Chr2:22803754-22858297 (+)
C57BL/6NJ ENSMUSG00215044201
 protein coding gene Chr2:22862498-22917044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023302
 protein coding gene Chr2:21754361-21809347 (+)
CAST/EiJ ENSTCUG00005052158
 protein coding gene Chr2:22568639-22621673 (+)
CBA/J ENSMUSG00210017247
 protein coding gene Chr2:22842705-22897242 (+)
DBA/2J ENSMUSG00185051229
 protein coding gene Chr2:22742258-22795637 (+)
FVB/NJ ENSMUSG00205039247
 protein coding gene Chr2:22596568-22651110 (+)
JF1/MsJ ENSUMUG00000046743
 protein coding gene Chr2:22645982-22699653 (+)
LP/J ENSMUSG00230042396
 protein coding gene Chr2:24673903-24728443 (+)
NOD/ShiLtJ ENSMUSG00190046032
 protein coding gene Chr2:22833085-22887628 (+)
NZO/HlLtJ ENSMUSG00225006563
 protein coding gene Chr2:32409691-32464901 (+)
PWK/PhJ ENSLUMG00010043361
 protein coding gene Chr2:22737612-22791218 (+)
SPRET/EiJ ENSMSPG00010045078
 protein coding gene Chr2:23426255-23480676 (+)
WSB/EiJ ENSIUOG00005047684
 protein coding gene Chr2:22690487-22744969 (+)



Homology
more
  • Human Ortholog
    KCNT1, potassium sodium-activated channel subfamily T member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNT1, potassium sodium-activated channel subfamily T member 1
  • Synonyms
    bA100C15.2, DEE14, EIEE14, ENFL5, KCa4.1, KNa1.1, SLACK, Slo2.2
  • Links
    NCBI Gene ID: 57582
    UniProt: Q5JUK3

  • Chr Location
    9q34.3; chr9:135702185-135795508 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kcnt1 mouse models; 2 with human KCNT1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 10 alleles in 12 genetic backgrounds
    5 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired action potential firing in sensory neurons and increased mechanical hypersensitivity in neuropathic pain models. Homozygosity for a gain-of-function mutation increases overall excitability of neurons and causes (nocturnal) seizures, hyperactivity and learning deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    14
  • cDNA Data
    23
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227632 NCBI Gene Model | MGI Sequence Detail 54479 C57BL/6J ±  kb
    transcript NM_001145403 RefSeq | MGI Sequence Detail 5931 C57BL/6  
    polypeptide Q6ZPR4 UniProt | EBI | MGI Sequence Detail 1224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000002080 potassium channel subfamily T member 1
      (term hierarchy)
    • InterPro Domains
      IPR003929 Calcium-activated potassium channel BK, alpha subunit
      IPR047871 Calcium-activated potassium channel slowpoke-like
      IPR013099 Potassium channel domain
      IPR003148 Regulator of K+ conductance, N-terminal lobe
    • GlyGen
      Q6ZPR4 5 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 23

      Microarray probesets 5
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:387999 Wang R, et al., Tonic-clonic seizures induce hypersomnia and suppress rapid eye movement sleep in mouse models of epilepsy. Sleep Adv. 2025;6(1):zpaf009
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory