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Dlg2 Gene Detail
Summary
  • Symbol
    Dlg2
  • Name
    discs large MAGUK scaffold protein 2
  • Synonyms
    A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, Gm21505, LOC382816, PSD93
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344351
    NCBI Gene: 23859
  • Alliance
  • Transcription Start Sites
    79 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:90125880-92098455 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 51.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55347 from dbSNP Build 142
  • Strain Annotations
    37
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344351
protein coding gene Chr7:90125399-92098455 (+)
129S1/SvImJ ENSMUSGG00200054826
protein coding gene Chr7:78500380-78879228 (+)
129S1/SvImJ ENSMUSG00200026922
protein coding gene Chr7:76896415-76923849 (+)
129S1/SvImJ ENSMUSGG00200054827
protein coding gene Chr7:77982268-78304257 (+)
A/J ENSMUSGG00195055180
protein coding gene Chr7:82482534-82812508 (+)
A/J ENSMUSG00195038518
protein coding gene Chr7:81420909-81448352 (+)
A/J ENSMUSGG00195055460
protein coding gene Chr7:83018767-83377837 (+)
AKR/J ENSMUSG00220041955
protein coding gene Chr7:74891972-74919409 (+)
AKR/J ENSMUSGG00220054678
protein coding gene Chr7:76488771-76847806 (+)
AKR/J ENSMUSGG00220054739
protein coding gene Chr7:75956289-76286289 (+)
BALB/cJ ENSMUSGG00180055451
protein coding gene Chr7:79158655-79488607 (+)
BALB/cJ ENSMUSGG00180055587
protein coding gene Chr7:79689557-80048611 (+)
BALB/cJ ENSMUSG00180036673
protein coding gene Chr7:78097191-78124635 (+)
C3H/HeJ ENSMUSGG00175054989
protein coding gene Chr7:80388028-80764790 (+)
C3H/HeJ ENSMUSGG00175054799
protein coding gene Chr7:79854288-80184247 (+)
C3H/HeJ ENSMUSG00175033100
protein coding gene Chr7:78787548-78814729 (+)
C57BL/6NJ ENSMUSGG00215055644
protein coding gene Chr7:79554687-79933809 (+)
C57BL/6NJ ENSMUSG00215020315
protein coding gene Chr7:77963087-77990296 (+)
C57BL/6NJ ENSMUSGG00215055640
protein coding gene Chr7:79031170-79360834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029988
protein coding gene Chr7:94120769-95431938 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054840
protein coding gene Chr7:80229855-80606597 (+)
CBA/J ENSMUSGG00210054810
protein coding gene Chr7:79696105-80026057 (+)
CBA/J ENSMUSG00210037874
protein coding gene Chr7:78629437-78656620 (+)
DBA/2J ENSMUSGG00185057745
protein coding gene Chr7:84025858-84355839 (+)
DBA/2J ENSMUSG00185030944
protein coding gene Chr7:82959090-82986269 (+)
DBA/2J ENSMUSGG00185057357
protein coding gene Chr7:84559622-84936370 (+)
FVB/NJ ENSMUSGG00205054310
protein coding gene Chr7:80192940-80551980 (+)
FVB/NJ ENSMUSGG00205054311
protein coding gene Chr7:79659224-79990513 (+)
FVB/NJ ENSMUSG00205029205
protein coding gene Chr7:78575359-78610027 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230016524
protein coding gene Chr7:89656670-91029551 (+)
NOD/ShiLtJ ENSMUSGG00190054980
protein coding gene Chr7:79902947-80232890 (+)
NOD/ShiLtJ ENSMUSG00190025281
protein coding gene Chr7:78841545-78868974 (+)
NOD/ShiLtJ ENSMUSGG00190054938
protein coding gene Chr7:80433834-80803834 (+)
NZO/HlLtJ ENSMUSGG00225055433
protein coding gene Chr7:88923708-89300437 (+)
NZO/HlLtJ ENSMUSG00225010950
protein coding gene Chr7:87323288-87350469 (+)
NZO/HlLtJ ENSMUSGG00225055662
protein coding gene Chr7:88389986-88719958 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010011466
protein coding gene Chr7:78134021-80188454 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DLG2, discs large MAGUK scaffold protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLG2, discs large MAGUK scaffold protein 2
  • Synonyms
    chapsyn-110, PPP1R58, PSD-93, PSD93
  • Links
    NCBI Gene ID: 1740
    UniProt: Q15700

  • Chr Location
    11q14.1; chr11:83455012-85628373 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052572 Ensembl Gene Model | MGI Sequence Detail 1972576 C57BL/6J ±  kb
    transcript ENSMUST00000231777 Ensembl | MGI Sequence Detail 7801 Not Applicable  
    polypeptide ENSMUSP00000155862 Ensembl | MGI Sequence Detail 994 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Other 1
      Antibodies 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1926130, MGI:2443779, MGI:2686043, MGI:5434860
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 13
      Gene Ontology 28
      Phenotypes 52
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/01/2026
    MGI 6.24
    The Jackson Laboratory