⭐ Must Read: News Update - ประเด็นร้อน

About the Journal

The journal ALTEX – Alternatives to Animal Experimentation publishes open access academic articles on the development and implementation of alternatives to the use of animals for scientific purposes and informs on international developments in this field.

ALTEX is the official organ of CAAT, CAAT-Europe, the Doerenkamp-Zbinden Chairs, EUSAAT and t⁴.

Announcements

NIH launches $7.1M Qu-SAFE Challenge to bring quantum sensing to NAMs-based toxicity testing

2026-10-09

Read more about NIH launches $7.1M Qu-SAFE Challenge to bring quantum sensing to NAMs-based toxicity testing

Science for Animal Welfare Centenary Research Award

2026-09-30

U.S. Department of Health and Human Services (HHS) accelerates shift to human-based research, reduces reliance on animal testing

2026-09-25

Current Issue

Vol. 43 No. 3 (2026)

View Vol. 43 No. 3 (2026)

Published: 2026-07-20

Editorial

Editorial

Sonja von Aulock

U2
- pdf
Alan Goldberg Obituary

Thomas Hartung

383
- pdf

Food for Thought ...

Exponential toxicology

Thomas Hartung

384-396
- pdf
Evidence-to-decision: From exposome data to evidence to action through agentic AI

Thomas Hartung

397-412
- pdf

Articles

Multiparametric evaluation of different FBS-free replacement media for widely used human cancer cell lines

Anne L. Koelz, Claudia Pommerenke, Pascal Woitschewski, Yvonne Merkhoffer, Wilhelm G. Dirks, Sonja Eberth

413-428
- pdf
- sup1
Validation study for the evaluation of MCTT HCE^™ test method for eye safety assessment of medical devices

Nam-Hee Kang, Seolyeong Kim, Subin Lee, Jungeun Park, Mi-Sook Jung, Hyo-Ju An, Min-Gyu Go, Joohwan Kim, Sun Wook Woo

429-441
- pdf
- sup1
- sup2
Implementation of reduction and refinement-related parameters in repeated dose toxicity studies

Katy Taylor, Laura Rego Alvarez, Emma Grange, David Andrew

442-452
- pdf
Investigation of the potential of bisphenol A substitutes to induce allergic contact sensitization using OECD defined approaches

Victor J. Johnson, Travis V. Gulledge, Michael I. Luster, Gary R. Burleson, Florence G. Burleson, Dori R. Germolec

453-463
- pdf
Serum-free in vitro assessment of receptor-mediated endocrine activity including Phase I metabolism

Inska S. Reichstein, Denise Horte, Rolf Marschalek, Eric Kowarz, Henner Hollert, Andreas Schiwy

464-482
- pdf
- sup
Tracing progress: The evolution of a protocol for relative metal release in surrogate gastric fluid

Adriana R. Oller, Pilar Prieto, Katherine Heim, João Barroso, Violaine T. Verougstraete

483-498
- pdf
- sup
Stakeholder input towards further refinement and consolidation of the Alternative Safety Profiling Algorithm (ASPA) for next generation risk assessment (NGRA)

Mirjam Luijten, Matthias Herzler, Femke Affourtit, Dave Allen, Muhammad Waqar Ashraf, Nicholas Ball, Elisabet Berggren, Sandra Berndt, Pierre-André Billat, Eike Cöllen, John Colbourne, Marco Corvaro, Richard Currie, Michael Guy Diemar, Hubert Dirven, Nadine Dreser, Sylvia E. Escher, Iain Gardner, Rafael Gozalbes, Stefan Hahn, Astrid Heiland, Claudia Hempt, Giel Hendriks, Oliver Henschel, Trine Husøy, Barira Islam, Keld Alstrup Jensen, Hennicke Kamp, Spyros Karakitsios, George E. N. Kass, Vikas Kumar, Robert Landsiedel, Thomas Loret, Patrik Lundquist, Catherine Mahony, Philip Marx-Stoelting, Martijn J. Moné, Ilse Ottenbros, Gladys Ouédraogo, Manuel Pastor, Magdalini Sachana, Sebastian Schmeisser, Stefan Scholz, Katrin Schütte, Kristie Sullivan, Silvia Tangianu, Adrian Tristram, Janette Turner, Mathieu Vinken, Jelle Vlaanderen, Bob van de Water, Andrew White, Marcel Leist

499-509
- pdf
- sup1
- sup2

Comments

Europe’s roadmap finally arrives: Long on rigor, short on a clock

Thomas Hartung

510-512
- pdf
Assessing the FDA’s Year One Progress Report on Reducing Animal Testing

Jon McCord, Joseph Manupello , Janine McCarthy, Shagun Krishna

513-515
- pdf

Meeting Reports

School of Animal Welfare and Ethics (SAWE) – 1^st Edition

Paola Fossati, Francesca Caloni, Jan Deckers, Andrea Gavinelli, Kirsten Persson, Marita Giménez-Candela, Piera Anna Martino, Emanuela Prato Previde, Daniela Takáčová

516-518
- pdf
INFOGUT – International Networking on In Vitro Colon Models Simulating Gut Microbiota-Mediated Interactions – 1^st Annual Meeting

Laure-Alix Clerbaux , Lorenzo Nissen, Pilar Acedo, Thomas Hitch, Enrique Carillo, Eliana Ibrahimi, Alise Ponsero, Harsh Mathur, Clarisse Nobre, Anthony Buckley, Jaroslav Havlik, Sabrina Tamburini, Lucie Etienne-Mesmin, Lidia Tomas, Jonatan Gomez-Raja, Stephanie Blanquet-Diot, Andrea Gianotti

519-522
- pdf
Understanding challenges and opportunities for the transition beyond animal experimentation in research and safety testing: What's new? What's next?

Nico D. Müller, Love Hansell, Simon Lohse

523-524
- pdf
Alternative methods, new approach methodologies (NAMs) and artificial intelligence (AI): Approaching the future of science

Francesca Caloni, Alessandra Cazzaniga, Arno C. Gutleb, Maurizio Gualtieri, Thomas Hartung, Helena Kandarova, Marisa Meloni, Hassan Rashidi, Doris Wilflingseder, María-José Ruiz

525-527
- pdf

Corners

Corners

528-540
- pdf

Imprint

Imprint

U3
- pdf

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