JBCS

The editorial presents the evolution of organic synthesis through the history of the Brazilian Meeting on Organic Synthesis (BMOS) and its special issues in JBCS. It highlights the expansion of synthetic strategies and tools as well as growing concerns with efficiency and sustainability. The text also emphasizes BMOS's role in researcher training, scientific collaboration, and the development of the Brazilian organic chemistry community. Celebrating the 20^th BMOS, the commemorative issue represents this long journey through an image inspired by the Odyssey, inviting readers to reflect on the Cyclops, Sirens, and Scylla and Charybdis encountered throughout their own scientific paths. BMOS is thus portrayed as an ongoing voyage of discovery, connecting people, ideas, and new possibilities in organic synthesis.

Synthesis of alg@hydrochar hydrobeads from Astrocaryum aculeatum for the efficient removal of Pb²⁺ and Hg²⁺ from effluents.

Covalent dialdehyde inulin-doxorubicin (DAI-DOX) conjugates and non-covalent sodium carboxymethyl inulin-doxorubicin (Na-CMI-DOX) complexes were developed as inulin-based carriers for doxorubicin. The covalent conjugates were found to be more structurally stable, retained anticancer activity and low acute toxicity, thus showing promise as a safer drug-delivery system.

This study investigates the molecular mechanisms and antiviral potential of Selaginella bryopteris phytoconstituents. Through drug-induced gene expression profile predictor (DIGEP-Pred), WebGestalt, and Cytoscape analyses, myo-inositol and amentoflavone emerged as key gene regulators enriched in estrogen and cancer-related pathways. Furthermore, 100 ns molecular dynamics simulations (MDS) confirmed the stable binding of amentoflavone to human immunodeficiency virus (HIV)-2 integrase, highlighting its strong potential as a novel lead antiviral therapeutic agent.

Small language models (SLMs) were used to analyze the abstracts from the proceedings of the biennial Brazilian Symposium of Theoretical Chemistry (SBQT) in the period of 1981-2023.

An intensified and efficient synthetic route was established for two key intermediates of the benchmark drug rivaroxaban, through continuous-flow nitro reduction and batch enzymatic kinetic resolution.

The editorial reflects on Prof. Andrade's career as a woman and mother in science and highlights the important role of the Journal of the Brazilian Chemical Society (JBCS) in supporting women researchers. It emphasizes mentorship, gender equality, recognition, and the need for scientific careers to accommodate family life. Prof. Andrade shows how journals, scientific societies, and professional networks can create a more inclusive academic environment, allowing women to pursue successful scientific careers while raising families and helping future generations of women chemists succeed.

A poly(D-glucosamine) alizarin carmine glassy carbon electrode (p-DG/AC/GCE) electrochemical platform was developed for the sensitive determination of raloxifene (RFN) by square-wave voltammetry. The sensor exhibited a detection limit of 0.9 nmol L^-1, a linear range of 0.001-10 µmol L^-1, and enabled accurate determination of RFN in pharmaceutical formulations and urine samples.

The leaf extracts of Eugenia protenta obtained with different solvents were evaluated by quantitative nuclear magnetic resonance (qNMR) and biological assays, revealing that methanol provided the highest gallic acid content, while alcoholic extracts showed the best overall antioxidant and antiglycation performance.

Portable energy-dispersive X-ray fluorescence (pXRF) and principal component analysis (PCA) enabled the in situ identification of iron as the main chromophore and the successful discrimination of six rock art sites.

This study demonstrates the uptake, translocation, and phase II glycosylation of metronidazole in plants, revealing active plant-mediated biotransformation supported by thin-layer chromatography (TLC) and ultra-high-performance liquid chromatography coupled with diode array detection and tandem mass spectrometry (UHPLC-DAD-MS/MS) analyses.

A copper nanoclusters (CuNCs)-based electrochemical sensor assisted by DNAzyme-driven catalytic hairpin self-assembly has been developed for the sensitive detection of human papillomavirus type 16 deoxyribonucleic acid (HPV16 DNA).

Side-chain length and halide identity modulate the structural organization, spectroscopic features, and preliminary antibacterial response of Cu^I-aminoquinoline complexes under solid-medium screening conditions.

Density functional theory (DFT) calculations were employed to investigated the electronic properties of carbon nanotube bundles (b-CNTs) intercalated with rubidium (Rb) and cesium (Cs). The intercalation of these alkali metals modifies the electronic structure of b-CNTs, shifting the Fermi level toward the conduction band. Noncovalent interaction (NCI) analysis was used to characterize the interactions between the intercalated atoms and the b-CNTs.

The OH radical chemical reactions with xenobiotic compounds in rivers, were studied using the RDKit library in Python, and a machine learning model were built to predict the toxicity (lethal dose 50% (LD₅₀)) of molecules.

An easy-to-assemble and affordable batch photoreactor that can operate parallel reactions is presented, from design to validation.

Three Stachys sp. were investigated for their phenolic contents, antioxidant/cytotoxicity properties, and acetylcholinesterase/tyrosinase inhibitory activities.

Static and continuous Ar atmospheres influenced the structure, morphology, porosity and electrochemical performance of porous Co-modified SiCO sensors.

Development of a sample preparation method for luminescent analysis of Zn^II 2-N-alkylpyridylporphyrin-based photosensitizers in biological matrix.

Miniaturized disposable pipette extraction using ionic liquid-intercalated montmorillonite enabled efficient extraction of low-molecular-weight polycyclic aromatic hydrocarbons from water samples with reduced solvent consumption. The optimized method showed satisfactory analytical performance for trace-level environmental monitoring.

This editorial argues that research ethics remain essential in the age of artificial intelligence (AI). While AI can improve efficiency and support scientific work, researchers are responsible for ensuring transparency, accuracy, integrity, and accountability. Ethical science depends on honest data, proper authorship, rigorous peer review, and critical human judgment, making AI a tool to assist - not replace - scientific reasoning.

Novel adamantane-derived Schiff bases were synthesized, characterized and evaluated for their antiviral activities in vitro over Zika, Mayaro, and chikungunya viruses. The (adamantan-1-yl)-1-(thiophen-2-yl)methanimine (atdTiof) and 2-{[1-(adamantan-1-yl)ethyl]iminomethyl}-4-fluorophenol (rtdFhba) exhibited the best inhibition rates of 58.5% over Zika and 69.5% over chikungunya, respectively.

Copper(II) thiosemicarbazone complexes showed promising anticancer activity against DU145 cells with cytotoxicity toward HEK293 cells.

Graphical abstract summarizing the synthesis, characterization, and adsorption performance of tucum activated carbon (TAC_1:1-3-350) for Ca²⁺ removal, highlighting the kinetic and isotherm models, adsorption efficiency, and thermodynamic behavior of the process.

The figure synthesizes the structural, thermal, and vibrational characterization of Tutton salts where potassium is partially replaced by rubidium.

Integrated molecular docking, molecular dynamics (MD) simulations, and density-functional theory (DFT) study of quercetin derivatives against Ebola VP30.

CO₂-mineralized basic oxygen furnace slag-supported NaNO₃ shape-stabilized phase change materials exhibited improved shape stability, enhanced thermal conductivity, and reliable performance after 300 cycles; CSS-60/OPT-N50 provided the best overall performance.

This paper reviews the research progress of spectroscopic technologies in food adulteration detection. Moreover, it provides a technical reference for promoting subsequent research and improving the practical application of spectroscopic methods in this field.

(In)organotelluroxides are the species that react with sulfur nucleophiles and organic species (organotelluranes and organotelluroxides) are more reactive than their inorganic counterparts.

This study identifies a furanocarboxamide derivative as a promising congenital toxoplasmosis hit, featuring an efficient four-step synthesis. Despite high permeability, its pharmacokinetic profile requires future optimization. Simulations against 26 essential Toxoplasma gondii enzymes revealed its most likely molecular targets.

Quantification of lactoferrin and fatty acids by high-performance liquid chromatography and gas chromatography in human milk at different stages of lactation and in commercial infant formulas.

Pd-Ni catalysts derived from cyanogel precursors exhibit enhanced glycerol electrooxidation activity in alkaline media.

Catalytic oxidative desulfurization of thiophene derivatives investigated by mass spectrometry reveals key oxidation intermediates and sulfur-removal pathways toward cleaner fuels.

Novel mechanochemical synthesis of bis(indolyl)methanes using sulfonic acid-functionalized chitosan as a green, metal-free catalyst.

Combined experimental and theoretical studies revealed unexpected limitations in productive formyl-directed hydrogen atom transfer (HAT)/decarboxylation reactivity of alkyl formates under photocatalytic conditions, providing mechanistic insights into alcohol diversification strategies.

Lipidomics workflow applied to serum samples to investigate acute kidney injury, integrating liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analysis with lipid annotation and multivariate statistical processing.

Reaction scheme illustrating the proposed synthetic route, with numbered indices highlighting the key aspects explored in this work.

Anacardium occidentale metabolic profiling; HPLC-DAD (high-performance liquid chromatography with diode-array detection) method to quantify agathisflavone; antimicrobial and cytotoxic evaluation.

Orientaline compound interacting expressively with the dopamine D2 receptor, corroborated by molecular docking techniques, molecular dynamics, energy decomposition, and free energy surface analysis.

A common modular building system is invoked as a metaphor for diversity‑oriented synthesis (DOS), where tricarbonylmethane building blocks enable divergent access to aminomethylene‑1,3‑diketones and dihydroquinazolinones.

Surface effective calcined magnetic biochar composite was synthesized by co-precipitation. Enhanced As^III and As^V removal were achieved in a high As-loaded aqueous medium. Characterization analyses revealed successful phase transformation during calcination. A cooperative set of mechanisms including electrostatic attraction, surface complexation, and precipitation were more pronounced.

Miniaturized chemistry and direct-to-biology approaches are shortcuts to accelerate and enhance the sustainability of drug discovery.

An environmentally relevant approach to the study of the sorption of hydrophilic pesticides onto polyethylene microplastics, including the use of real water matrices and comparison of the sorption capacity with that of natural sorbents, is presented.

Advanced enabling technologies, including microwave irradiation, continuous flow chemistry, and mechanochemistry, drive biomass valorization toward the efficient production of high-value compounds.

A 3-step synthesis of 2,4,5-trisubstituted imidazoles featuring a Pd-catalyzed arylation of aryl methyl ketone, SeO₂-oxidation to yield 1,2-diketones and Debus-Radziszewski condensation.

The editorial highlights how the Journal of the Brazilian Chemical Society is modernizing its editorial practices through digital tools, open science principles, and a new training program. This first SBQ Editorial Training prepared selected researchers in areas like peer review, ethics, and publishing platforms, strengthening editorial quality, integrity, and future sustainability. The initiative proved successful and is expected to expand, reinforcing the journal's commitment to excellence and reliable scientific communication.

Efficient microwave-assisted Knoevenagel-Doebner condensation for the synthesis of 3-aryl acrylic acids, in which pyridine acts simultaneously as both solvent and base, providing high reactant conversion.

Soil macrofauna metal interactions under different cacao management systems.

Potential inhibitory activity of curcumins against SARS-CoV-2 protein shown through docking, molecular dynamics (MD) and HOMO-LUMO gap (highest occupied molecular orbital and the lowest unoccupied molecular orbital, respectively).

A guide for X-H insertion reactions (N-H, O-H, S-H) with sulfoxonium ylides is described, employing several metal catalysts. Thirteen different products are obtained from substituted and non-substituted keto-, ester- and amide-sulfoxonium ylides.

The study evaluated the pretreatment of cupuaçu peel using choline chloride-based deep eutectic solvents combined with ultrasound and autoclave methods. These procedures resulted in greater carbohydrate release and optimized the synthesis of furanic compounds.

A lipophilic aggregation-induced enhanced emission (AIEE) active benzothiadiazole enables high-contrast fingerprint imaging with high ridge/furrow differentiation and level-3 detail resolution.

First-row (3d) transition metal-catalyzed aromatic C‒H activation offers new opportunities in more sustainable late-stage functionalization.

In the organocatalytic [3 + 2] cycloaddition of nitrones to propargylic aldehydes, silyl-protected prolinol catalysts are rapidly consumed via nucleophilic addition to the iminium intermediate, halting the reaction. Unprotected prolinol catalysts circumvent this by forming off-cycle hemiaminals, which sequester the catalyst and enable productive cycloaddition.

This graphical abstract summarizes the development of a microwave-assisted reductive amination protocol, highlighting reaction optimization and product distribution. It emphasizes the competing formation of tertiary amines.

The flowchart shows the phytochemical study of Croton argyrophylloides, from collection and botanical identification to extraction, fractionation, and isolation of metabolites. The fractions obtained were analyzed by spectroscopic and spectrometric techniques for structural elucidation and identification of the isolated compounds.

This review provides a comprehensive overview of DBU-driven azide-based [3 + 2] cycloaddition reactions for the metal-free synthesis of 1,2,3-triazoles. Key transformations are organized into three categories: azide-carbonyl cycloadditions, reactions with activated alkenes, and multicomponent/tandem processes, with emphasis on substrate scope, regioselectivity, mechanistic features, and synthetic applications.

Chemistry is framed as the core of all omics fields, even in a data-driven era. In Brazil, omics research is expanding, but still limited by unequal access to equipment, dependence on imports, and training gaps. The text warns against the global "identification illusion," stressing the need for solid chemical validation. It highlights the Journal of the Brazilian Chemical Society as a driver of quality and scientific progress. Brazil's future in omics relies on uniting analytical rigor, computational capacity, and strategic focus to produce reliable, impactful knowledge.

This review presents the main minor phytocannabinoids, covering their isolation, proposed biosynthetic pathways, and reported biological activities, with particular emphasis on synthetic strategies.

Appropriate additives can effectively regulate the key physicochemical properties of aluminum chloride-1-ethyl-3-methylimidazole chloride (AlCl₃-EMImCl). 1,2-Dichloroethane (DCE) and tetrahydrofuran (THF) are considered promising candidates to improve the dynamic properties of AlCl₃-EMImCl electrolytes for aluminum-ion battery applications.

This work introduces α-nitroolefins as a new platform for selective access to 1,4-triazoles by a cycloaddition step controlled by frontier molecular orbital (FMO) and distortion energy.

A green and convenient synthesis of N-(4-bromophenyl) ureas as potential fungicides against Colletotrichum lindemuthianum.

Hyperspectral imaging was used to acquire spectral data from stamp inks, and machine learning algorithms were applied to estimate the time elapsed since the stamp was applied in the proposed approach, which offers a non-destructive and objective tool for forensic document examination.

C3-functionalized 4-hydroxycoumarins show promising fluorescent platforms for the development of optical sensors for heavy metal monitoring in environmental and consumer products.

A new method for determining Fe, Mn, and Zn in soy milk samples after dissolution in tetramethylammonium hydroxide was developed.

Chromene-dihydropyrimidinone (Chro-DHPM) hybrids as urease inhibitors.

Specific oxidation chemical reactions with volatile organic compounds (VOCs) were studied using the RDKit library in Python and machine learning models were built to predict the mutagenicity of molecules.

Synthesis of 2-styrylbenzothiazole and 2-styrylbenzimidazole derivatives with potential anticancer activity.

Workflow employed to profile Amaryllidaceae alkaloids through liquid chromatography-mass spectrometry (LC-MS), molecular networking, and bioactivity assays, linking metabolite composition to antileishmanial potential.

This work presents the physicochemical characterization and comparison of vegetable oils from different sources, as well as their chemical modification and the application of resulting monomers in vat photopolymerization 3D printing.

Untargeted ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry with MSE acquisition (UPLC QTOF-MSE) metabolomics combined with machine learning was applied to plasma from free-ranging neotropical primates. Distinct metabolic signatures associated with Toxoplasma gondii infection were identified, highlighting potential biomarkers of toxoplasmosis.

Biochar and bio-oil from the conversion of pine wood and sugarcane straw biomasses through slow and fast pyrolysis in a fixed-bed reactor is reported. A comparison of the yield under different experimental conditions and a full characterization of the products contributed to the understanding of the potential of both biomasses.

Experimental design to evaluate the effects and interactions of electrolyte pH and cathode rotation on Mo content in electrodeposited Ni-Mo alloys under Ni-rich bath conditions and corrosion resistance evaluation.

A sustainable low-energy impact mechanochemical method for the synthesis of 5-amino-1H-1,2,3-triazoles from phenylacetonitriles and arylazides was developed. Under solvent-free conditions and using SiO₂ as a milling auxiliary, sixteen examples of 5-aminotriazoles were obtained in good yields (up to 79%). The method features in short reaction times and simple product isolation by a column filtration, avoiding laborious workup procedures.

Plasma samples from Alzheimer's disease (AD) patients before and after acetylcholinesterase inhibitor treatment were analyzed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) based untargeted metabolomics and lipidomics. Statistical and pathway analyses revealed metabolic signatures associated with treatment response and disease-related dysfunctions.

An integrated metabolomics approach combining gas chromatography mass spectrometry (GC-MS) and anti-inflammatory assay workflows to monitor seasonal chemical and bioactivity variations in Ocotea odorifera essential oils.

Leaf spray profiling guided extract preparation for liquid chromatography-mass spectrometry (LC-MS) analysis, while feature-based molecular networking (FBMN) enabled the annotation of glycoside clusters in Strychnos jobertiana leaves.

Analysis of volatile compounds by headspace solid-phase microextraction gas chromatography coupled with mass spectrometry (HS SPME/GC-MS) and non-volatiles by ultrahigh-performance liquid chromatography-high resolution tandem mass spectrometry (UHPLC-HRMS/MS) enabled a comprehensive metabolite annotation of the unconventional food plant Theobroma mariae.

From lettuce leaves to chemical fingerprints, paper spray mass spectrometry and chemometrics unveil the hidden differences among samples.

¹H HR-MAS NMR (high-resolution magic-angle spinning nuclear magnetic resonance)-based metabolomics of transgenic Swingle citrumelo leaves reveals adaptive metabolic adjustment under water stress.

Some N-arylsuccinimides can be obtained directly from arenes using N-bromosuccinimide (NBS).

Cu^II complexes show promising antimicrobial and anticariogenic activity with low in vivo toxicity and strong anti-biofilm effects.

Extraction of psilocybin from Psilocybe cubensis mushrooms and optimization of the process by factorial design.

Graphical abstract illustrating the conversion of caffeine, present in coffee fruits, into a derivative with anticholinesterase activity.

CAPES introduced new evaluation rules for graduate programs (2025-2028), shifting focus from journal-based Qualis rankings to article-level assessment. Articles will now be classified into strata A1-A8 combining bibliometric and qualitative criteria. Procedure 1 relies on journal metrics (similar to Qualis), while Procedure 2 adds qualitative aspects and article impact indicators. The new model values research quality more directly and highlights impactful articles regardless of journal prestige. It also strengthens Brazilian journals and open science initiatives like SciELO, promoting regional development and responsible research assessment.

This figure presents a macrolide drug repositioning strategy using computational methods. It shows a virtual screening pipeline that integrates databases and a quantitative structure-activity relationship (QSAR) model to prioritize macrolides with potential therapeutic effects against Schistosoma mansoni thioredoxin glutathione reductase (SmTGR).

Terahertz time-domain spectroscopy (THz-TDS) was used to distinguish salicylic acid and acetylsalicylic acid, and qualitative and quantitative analysis of the weak interaction between the two similar substances was conducted using interaction region indicator (IRI), energy decomposition analysis based on force-field (EDA-FF), and electrostatic potential (ESP) methods.

Graphical abstract showing a PCA (Principal Component Analysis) biplot (PC1 = 63.3%; PC2 = 23.1%) highlighting the separation of early growth stages (I), intermediate growth stages (G), and maturation stages (M), and their differential association with phenolic compounds and hormonal regulators throughout fruit development.

1-Butyl-3-methylimidazole lysine ([BMIm]Lys) exhibits significantly higher CO₂ absorption capacity. Meanwhile, [BMIm]Lys synergistically captures CO₂ with zirconium aminobenzenedicarboxylate metal-organic framework (NH₂-UiO-66(Zr)).

Scientific journals are central to research, ensuring dissemination, validation, and reproducibility of knowledge through peer review and rigorous standards. The Journal of the Brazilian Chemical Society plays a key role in promoting Brazilian research globally and strengthening academic-industrial connections. The innovation system in Brazil has advanced through collaboration between universities, industry, and agencies like FINEP and CNPq, though challenges remain in funding, infrastructure, and culture. Issues such as publication bias, metric-driven incentives, and hype threaten scientific integrity, highlighting the need for reforms like open science, transparency, and stronger peer review.

Isabelcristinia aromatica is a new species recently described to the Caatinga biome, and this is the first phytochemical study with this species.

Decarbonation of rock samples for organic matter maturity evaluation mitigated Raman spectroscopy experimental issues, producing geologically coherent maturity data.

Effect of biodegradable cassava starch-based coating on the appearance of strawberries during storage. Both groups exhibit darkening and structural loss, showing similar deterioration.

Five new Cu^I-4,7-dichloroquinoline polymeric or dimeric complexes display halide-dependent solid-state photoluminescence arising from charge-transfer (CT) excited states.

Quantification of organochlorines pesticides in blood plasma by gas chromatography-coupled to mass spectrometry (GC-MS/MS) from 127 vector control workers from Rio de Janeiro. The analysis detected residues of dichlorodiphenyltrichloro-ethane (DDT) isomers and related transformation products in 52% of individuals, and beta-hexachlorocyclohexane (HCH) in 12%.

Propolis samples were collected and processed into ethanolic extracts, which were characterized by liquid chromatography-mass spectrometry (LC-MS) and UV-Vis spectroscopy. Multivariate analysis, correlation methods, and compound annotation were employed to integrate the chemical profiles with visible absorption features, yielding insights into the chemical diversity of propolis and its relationship to color.

This review integrates toxicometabolomics approaches to elucidate the biochemical complexity of new psychoactive substances (NPS). Across major NPS classes, studies employing liquid chromatography-tandem mass spectrometry (LC-MS/MS), to high-resolution mass spectrometry (LC-HRMS), and gas chromatography-mass spectrometry (GC-MS), in vitro and in vivo models are critically analyzed. Strategies to enhance standardization, reproducibility, and translational impact are proposed.

Short, high-yielding five-step synthesis of erlotinib.

Schematic representation of the combined magnetic solid-phase extraction cloud point extraction (CPE-MSPE) approach using a Moringa oleifera-based magnetic adsorbent for cadmium extraction, preconcentration, and determination by flame atomic absorption spectrometry (FAAS).

This in silico study explores chromone-based derivatives as selective cyclooxygenase-2 (COX-2) inhibitors, aiming to identify potential anti-inflammatory agents.

Comparative metabolic profiling revealed interspecific variation among Cololobus species, with a high prevalence of phenolic compounds and sesquiterpene lactones. Species from harsher inselbergs exhibited greater chemical diversity, reflecting plant responses to extreme environments.

Extraction of cembratrien-diol from tobacco inflorescences by deep eutectic solvent and recovery by liquid-liquid extraction. The separation of the two cembratrien-diol occurred by semi-preparative high performance liquid chromatography.

The diagram illustrates the use of self-organizing maps (SOMs) for the chemotaxonomic analysis of the Erythrina and Sophora genera (Fabaceae family). The study integrates chemical and biological activity data of alkaloids to identify chemomarkers and link activities to specific metabolite scaffolds, validating the taxonomic separation of the genera.

The graphical abstract summarizes a non-invasive screening for coronavirus disease (COVID-19) based on urine analysis by capillary zone electrophoresis with ultraviolet detection (CZE-UV) and machine learning-driven classification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive and -negative individuals.

Dried urine spots (DUS) were analyzed using untargeted liquid chromatography-high-resolution mass spectrometry (LC-HRMS) metabolomics to investigate Pompe disease (PD).

A clinical-to-chemistry snapshot of the 2025 approvals of the Food and Drug Administration (FDA), this review compiles the small-molecule drug substances of the year and connects each one to its therapeutic target and synthetic steps. The result is a curated map of 2025 innovation to guide deeper synthetic and strategic analyses.

This study outlines a proteomic workflow investigating how chronic 2,3-butanedione exposure alters brain protein expression in Wistar rats, integrating sample preparation, liquid chromatography-mass spectrometry (LC-MS/MS) analysis, and advanced data processing to reveal pathway-level molecular alterations.

Schematic representation of the study workflow to investigate the metabolic phenotype of Cri-du-Chat syndrome. Urine samples underwent nuclear magnetic resonance (NMR)-based metabolomic profiling followed by statistical data analysis, enabling the identification of metabolic alterations associated with different age groups.

The use of plant growth-promoting yeasts (PGPYs) affects the metabolite profile and metabolic pathways in tomato seedling leaves.

The editorial addresses changes in the evaluation of Graduate Programs in Chemistry by CAPES (2025-2028), emphasizing strategic planning, inclusion, and social impact. It highlights a shift from quantitative metrics to qualitative assessments tailored to the specific context of each program. The importance of faculty and student inclusion, the reduction of regional inequalities, and solidarity among programs is also underscored. Finally, it stresses the central role of Chemistry in addressing societal challenges and the UN Sustainable Development Goals.

The application of normalization strategies is fundamental for reducing unwanted analytical variability and determining accurate biological significance in metabolomics studies.

This proteomic approach shows how passion fruit seed oil (PFSO), a sustainable phytogenic, modulates metabolic pathways and enzymatic profiles. These molecular shifts mitigate heat stress, ensuring broiler health and environmental resilience in the poultry industry.

HKUST-1 (metal-organic framework (MOF) with the formula [Cu₃(BTC)₂(H2O)₃]_n (BTC: benzene-1,3,5-tricarboxylate)) modified with gold nanoparticles (AuNPs) degrades in water but remains stable in DMF (N,N-dimethylformamide) and can be regenerated with ethanol.

Gold mining, often carried out illegally, is severely contaminating the rivers of the Amazon region with mercury. Consequently, mercury levels in fish are increasing, degrading the environment and affecting human health.

Artemisia herba-alba essential oil (uncommon chemotype): a significant biopesticide showing high efficacy against the apple pest Cydia pomonella.

Adulteration, such as the partial or total substitution of buffalo whey with cow whey, can compromise the quality, nutritional characteristics, and safety of the food. Furthermore, ensuring authenticity is essential to meet regulatory requirements and to enhance the value of products with a geographical indication.

Quinazoline-dihydropyrimidinones hybrids are potent against Trypanosoma cruzi and Leishmania parasites, surpassing miltefosine and benznidazole drugs.

The results found in this study suggest that anthropogenic activities and occurrences of El Niño Southern Oscillation climate phenomena alter hydrochemical parameters in a tropical river over the years.

A concise and biomimetic total synthesis of the antimitotic (+)-2,3,9-trimethoxypterocarpan is reported. The route features a ligand-free Suzuki coupling and a Ru-catalyzed asymmetric transfer hydrogenation coupled with dynamic kinetic resolution (ATH-DKR), affording the API candidate in 64% overall yield with high optical purity.

This study shows that combining 2D and molecular interaction field (MIF) descriptors improves the prediction and interpretation of dopamine transporter (DAT) inhibition by methylamine derivatives.

High performance liquid chromatography coupled with mass spectrometry (HPLC-MS) and chemometric tools revealed significant differences in metabolome regarding diet and exercise practices.

This study focuses on the use of silica extracted from rice husk ash as a support for metals. The supported materials were evaluated for carbon dioxide (CO₂) sorption and their performance in dimethyl carbonate (DMC) conversion.

Blood plasma samples from healthy and human immunodeficiency virus (HIV)-infected pregnant women were analyzed by excitation-emission matrix (EEM) fluorescence spectroscopy, resulting in three-way data. Chemometric modeling using Tucker3-QDA (Tucker3-quadratic discriminant analysis) and n-PLS-DA (n-way partial least squares discriminant analysis) algorithms allowed the classification of samples into case and control groups.

The figure illustrates the preparation of a stable emulsion consisting of butanol, gasoline, and aqueous ethanol in precise proportions, as indicated by the labels on each flask. The components were combined and stirred until a stable emulsion was formed. The resulting emulsions were evaluated for fuel specifications, including density/specific gravity (SG), research octane number (RON), Reid vapor pressure (RVP), copper strip corrosion resistance, and distillation characteristics.

This study analyzed the oil from Paliurus spina-christi Mill. seeds gathered across Turkey in the course of two years. To determine if it may be used in vegetable oil technology, researchers examined its thermal, structural, and chemical characteristics.

The schematic illustrates the synergistic integration of photoassisted, sonochemical, and electrochemical flow processes for the degradation of pesticides in aqueous solution, highlighting the generation of oxidizing species and the high efficiency in total organic carbon removal.

Validation of a high-performance liquid chromatography (HPLC-UV-Vis) method for identification of glycerol ethers.

This work presents recent advances in the chemistry of sulfur-linked glycosides, focusing on modern synthetic approaches to functionalized 1-thioglycosides and their relevance in medicinal chemistry.

Reanalysis of skin metabolomics dataset reveals disrupted N-acyl lipids in atopic dermatitis, linking to personal care, microbes, and barrier dysfunction.

The editorial addresses changes in the evaluation of Graduate Programs in Chemistry by CAPES (2025-2028), emphasizing strategic planning, inclusion, and social impact. It highlights a shift from quantitative metrics to qualitative assessments tailored to the specific context of each program. The importance of faculty and student inclusion, the reduction of regional inequalities, and solidarity among programs is also underscored. Finally, it stresses the central role of Chemistry in addressing societal challenges and the UN Sustainable Development Goals.

Synthesis of novel piperine-based esters and thiazole hybrids with dual antibacterial and antibiotic-modulating activity, highlighting their ability to inhibit efflux pumps and enhance the efficacy of conventional antibiotics against resistant bacterial strains.

Combination therapy improves cancer remission. This study evaluates the in silico and in vitro association of a pterocarpan and vorinostat as an epigenetic antitumor strategy, integrating target mapping, molecular docking, and viability assays. The combination enhanced antiproliferative efficacy and mitigated limitations of individual compounds.

Sustainable films using collagen recovered from leather waste and Hymenaea martiana extract. Bioactive films showed high tensile strength, flexibility and hydration capacity, revealing its potential to wound treatment applications.

Preparation of nanometric films using the layer-by-layer technique and their functionalization with amino acids from the last layer to determine the degree of adhesion of Escherichia coli.

Electrochemical method for ivermectin quantification in different matrices.

A streamlined synthesis yielded a flavonoid derivative with confirmed structure and strong antioxidant and anticancer activities, highlighting its potential as a multifunctional therapeutic scaffold.

This research validates oxypeucedanin hydrate (OPH) as a promising anti-cancer agent against ovarian cancer by targeting phosphoserine aminotransferase 1 (PSAT1). Computational studies showed that OPH has superior binding affinity (dG) and stability compared to a reference drug. Its favorable pharmacokinetics suggest it could be developed as an effective oral therapeutic to suppress tumor growth.

Cu²⁺-crosslinked alginate/ι-carrageenan hydrogel as an efficient reusable catalyst for Paal-Knorr reaction.

A platinum complex associated with a microemulsion was characterized using physicochemical methods and evaluated in biological assays, which demonstrated its immunomodulatory activity.

The study reports the optimization process of ultrasound-assisted extraction using the response surface method by evaluating total phenolic compounds and inhibition of DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. The process resulted in an extract with bioactive potential in which the presence of ellagic acid and its derivatives were identified.

We developed two distinct routes to obtain bioactive peptides from chicken blood meal: (i) an enzymatic process with Alcalase, and (ii) a non-enzymatic high-temperature alkaline process.

Study of the stability of the composition and nutritional quality of fatty acids in human milk stored under different conditions for 90 days.

The Journal of the Brazilian Chemical Society (JBCS) delivers strong scientific, social, and translational impact through all areas of chemistry. To enhance editorial excellence, the JBCS has restructured its governance, professionalized editorial practices, improved author and reviewer guidelines, and significantly reduced decision times while adopting modern publication models. These initiatives have strengthened the journal's quality, visibility, and relevance.

A review of the potential of using active compounds from unconventional edible sources in the production of sustainable food packaging.

This study demonstrates the immobilization of lipase B from Candida antarctica on magnetic nanoparticles to catalyze the enantioselective esterification of (R,S)-ibuprofen, enabling the efficient synthesis of ibuprofen ethyl ester. The system offers enhanced stability and catalytic performance for biocatalytic applications.

The conversion of whey lactose into lactic acid by Kluyveromyces marxianus, integrating fermentation kinetics and system rheology.

Porous sodium super ionic conductor (NASICON)-type glass-ceramics were obtained from Li₂O-GeO₂-CaO-P₂O₅ glasses by controlled heat treatment and acid leaching, enabling tunable pore morphology and selective NASICON phase formation for energy, catalytic, and sensing applications.

This study compares conventional and solar-powered electrocoagulation for the removal of acetylsalicylic acid (ASA) from wastewater. Solar integration achieved > 80% removal efficiency, promoted colloidal destabilization (zeta potential (ζ) = -2 mV, large flocs > 10 000 nm), and reduced operational costs (0.20-0.73 R$ m^-3), demonstrating a sustainable and economically advantageous treatment alternative.

The picture is an illustration of the experimental scheme for preparing and characterizing Bi_2-xSb_xTe₃ film.

The response surface method effectively predicts the optimal dyeing conditions for Color Index (C.I.) Acid Blue 90 on nylon 66. The color yield reaches a high value of 37.1 when using 4% weight of fabric (o.w.f.); its uptake follows the Langmuir-Nernst isotherm equation and the pseudo-second-order kinetic model.

Thermal decomposition kinetics of three corticosteroids were investigated using the Vyazovkin Method and Multilayer Perceptron Network (MLP) neural network.

Structural elucidation by nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS), electronic circular dichroism (ECD), and computational methods of a novel alkylresorcinol isolated from Eugenia citrifolia, and evaluation of its antioxidant potential using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays.

Surfactant-free microemulsions (SFME) with high water content (76%) combined with fluorescence spectroscopy enable citrus essential oils differentiation.

This figure illustrates the characterization and mechanism studies of the inhibitory effects of three curcuminoids on lactose-induced β-lactoglobulin (BLG) glycation.

Correct conformational analysis of furofuran lignans by vibrational circular dichroism (VCD) spectroscopy requires explicit solvation even for non-coordinating solvents.

Cocoa butter obtained from different varieties (BN34, CCN51, and PS1319) has a similar chromatographic and spectroscopic profile but exhibits distinct properties, particularly in terms of melting point and thermal stability.

Metabolomics analysis revealed resistance-associated biomarkers in dwarf cashew genotypes under black mold stress caused by leaf pathogenic fungi. This approach highlights key metabolic pathways linked to plant defense.

Sapientrione (1), a nor-triterpene with an unprecedented skeleton type was isolated from the roots of Sapium glandulosum (Euphorbiaceae). The antimycobacterial activity and cytotoxicity of the new compound (1) and its derivative (2) were evaluated.

This study aimed to develop an alternative chemometric method to establish the origin of cigarette brands sold in Brazil.

This work explores the metal-organic frameworks (MOF-5) doped with Eu and EuMn as a temperature sensor in the range between 229-393 K.

Zinc bismuthate-based nanocomposites synthesized by a hydrothermal route exhibited selective antimicrobial activity and moderate toxicity, highlighting their potential for biomedical applications.

The figure illustrates the targeted quantification of bioactive compounds from Anacardium humile and Anacardium occidentale using high-performance liquid chromatography mass spectrometry (HPLC-MS/MS), followed by an evaluation of their antioxidant capacity via the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.

Exposure routes to bisphenol A from drinking water and thermal paper, with urinary excretion as a biomarker.

This graphical abstract illustrates how extraction methodology can alter the perceived volatile profile of Mikania sp. The resulting chemical message can directly influence which cues are available to insects, highlighting that methodological choice is critical in chemical ecology studies.

Development and analysis of the influence of hybrid natural rubber (NR) systems, incorporated with CaP and SiP, on the morphology, enzymatic activity (alkaline phosphatase) and viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay) of murine osteoblasts.

Hydrothermally carbonized hydrochar from banana peel for the removal of iron and manganese from water.

Polyvinyl alcohol (PVA) associated with carbonized Kraft lignin produced in four ratios (0, 10, 30, and 50%), characterizations and application as gas detector.

Extraction and preconcentration of diuron in environmental waters and soymilk samples using a bifunctional hybrid molecularly imprinted polymer (BHMIP) as a selective adsorbent in solid phase extraction (SPE) followed by high-performance liquid chromatography with diode array detector (HPLC-DAD) determination.